R
Ronald M. Evans
Researcher at Salk Institute for Biological Studies
Publications - 729
Citations - 176865
Ronald M. Evans is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Nuclear receptor & Receptor. The author has an hindex of 199, co-authored 708 publications receiving 166722 citations. Previous affiliations of Ronald M. Evans include Scripps Research Institute & University of California, Davis.
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Journal ArticleDOI
Identification of a nuclear receptor that is activated by farnesol metabolites
Barry M. Forman,Elizabeth Goode,Jasmine Chen,Anthony E. Oro,David J. Bradley,Thomas Perlmann,Daniel J. Noonan,Leo T. Burka,Trevor C. McMorris,William W Lamph,Ronald M. Evans,Cary Weinberger +11 more
TL;DR: The results suggest that metabolite-controlled intracellular signaling systems are utilized by higher organisms as transcriptional regulators in bacteria and yeast.
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LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Patricia J. Willy,Kazuhiko Umesono,Estelita S. Ong,Ronald M. Evans,Richard A. Heyman,David J. Mangelsdorf +5 more
TL;DR: Evidence is provided that the retinoid response on the LXRE is the result of a unique interaction between LXR alpha and endogenous RXR, which, unlike in the RXR/RAR heterodimer, makes RXR competent to respond to retinoids.
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Regulation of muscle fiber type and running endurance by PPARδ
Yong-Xu Wang,Chun Li Zhang,Ruth T. Yu,Helen K. Cho,Michael C. Nelson,Michael C. Nelson,Corinne R. Bayuga-Ocampo,Jungyeob Ham,Heonjoong Kang,Ronald M. Evans,Ronald M. Evans +10 more
TL;DR: The engineering of a mouse capable of continuous running of up to twice the distance of a wild-type littermate is described, achieved by targeted expression of an activated form of peroxisome proliferator-activated receptor δ (PPARδ) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers.
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PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation.
TL;DR: It is demonstrated that PPAR-γ is neither essential for nor substantially affects the development of the macrophage lineage both in vitro and in vivo, and that inhibitory effects on cytokine production and inflammation may be receptor independent.
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AMPK and PPARδ Agonists Are Exercise Mimetics
Vihang A. Narkar,Michael Downes,Ruth T. Yu,Emi Embler,Yong-Xu Wang,Ester Banayo,Maria M. Mihaylova,Michael C. Nelson,Yuhua Zou,Henry Juguilon,Heonjoong Kang,Reuben J. Shaw,Ronald M. Evans,Ronald M. Evans +13 more
TL;DR: It is found that PPARbeta/delta agonist and exercise training synergistically increase oxidative myofibers and running endurance in adult mice and demonstrates that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise.