R
Ronald M. Evans
Researcher at Salk Institute for Biological Studies
Publications - 729
Citations - 176865
Ronald M. Evans is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Nuclear receptor & Receptor. The author has an hindex of 199, co-authored 708 publications receiving 166722 citations. Previous affiliations of Ronald M. Evans include Scripps Research Institute & University of California, Davis.
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Journal ArticleDOI
Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity.
Dinah L. Misner,S. Jacobs,Yohko K. Shimizu,A. M. de Urquiza,Ludmila Solomin,Thomas Perlmann,L M De Luca,Charles F. Stevens,Ronald M. Evans +8 more
TL;DR: The results demonstrate that vitamin A and its active derivatives function as essential competence factors for long-term synaptic plasticity within the adult brain, and suggest that key genes required forlong-term potentiation and long- term depression are retinoid dependent.
Journal ArticleDOI
FXR Regulates Intestinal Cancer Stem Cell Proliferation.
Ting Fu,Sally Coulter,Eiji Yoshihara,Tae Gyu Oh,Sungsoon Fang,Fritz Cayabyab,Qiyun Zhu,Tong Zhang,Mathias Leblanc,Sihao Liu,Mingxiao He,Wanda Waizenegger,Emanuel Gasser,Bernd Schnabl,Annette R. Atkins,Ruth T. Yu,Rob Knight,Christopher Liddle,Michael Downes,Ronald M. Evans +19 more
TL;DR: It is shown that the convergence of dietary factors and dysregulated WNT signaling alters BA profiles to drive malignant transformations in Lgr5-expressing cancer stem cells and promote an adenoma-to-adenocarcinoma progression.
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The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression
Philippe Dhordain,Richard J. Lin,Sabine Quief,Danièle Lantoine,Jean-Pierre Kerckaert,Ronald M. Evans,Olivier Albagli +6 more
TL;DR: It is concluded that LAZ3 recruits a repressing complex containing SMRT, mSIN3A and a HDAC, and that its full repressing potential on transcription requires HDACs activity.
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An essential role for retinoid signaling in anteroposterior neural patterning
TL;DR: It is shown that increased receptor activity suppresses anterior neural structures while dominant negative receptors lead to anterior enhancement and microinjection of the dominant negative receptor leads to the loss of posterior marker genes.
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The peroxisome proliferator-activated receptors: ligands and activators.
TL;DR: PPAR alpha and PPAR gamma represent related but distinct members of the nuclear receptor superfamily whose signaling is modulated by long-chain fatty acids, whereas PPAR Gamma ligands are potent antidiabetic agents.