Ronald M. Evans

TL;DR: It is demonstrated that unusual and, in some cases, previously impossible cloning strategies can be readily and efficiently achieved as long as the flanking sequences of the linear vectors are highly related.

TL;DR: The results suggest that the importance of activin-related signaling pathways is not confined to pregastrulation stages and that these receptors may be involved in mediating the effects of inducing signals during later stages of development of the mesoderm, limbs, and nervous system.

TL;DR: The use of human glucocorticoid receptor mutants to identify regions important for trans-repression of the gene encoding the alpha subunit of chorionic gonadotropin suggests a potentially general strategy for creation of sequence-specific transcriptional repressors.

TL;DR: The results suggest the possibility that a pathway for suppression of hypertrophy may exist in vivo, which may have potential therapeutic value.

TL;DR: It is shown that REV-ERBα, a core inhibitory component of clock transcription, is targeted for ubiquitination and subsequent degradation by the F-box protein FBXW7, which defines an unexpected molecular mechanism for re-engaging the positive transcriptional arm of the clock, as well as a potential route to manipulate clock amplitude via small molecule CDK1 inhibition.