R
Roop K. Khar
Researcher at Hamdard University
Publications - 159
Citations - 11605
Roop K. Khar is an academic researcher from Hamdard University. The author has contributed to research in topics: Drug delivery & Drug carrier. The author has an hindex of 50, co-authored 155 publications receiving 10410 citations. Previous affiliations of Roop K. Khar include Jamia Hamdard.
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Journal ArticleDOI
Stability indicating high-performance thin-layer chromatographic determination of gatifloxacin as bulk drug and from polymeric nanoparticles.
Sanjay K. Motwani,Roop K. Khar,Farhan Jalees Ahmad,Shruti Chopra,Kanchan Kohli,Sushma Talegaonkar,Zeenat Iqbal +6 more
TL;DR: The statistical analysis proves that the developed method for quantification of gatifloxacin as bulk drug and from polymeric nanoparticles is reproducible and selective.
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Formulation and development of floating capsules of celecoxib: in vitro and in vivo evaluation.
TL;DR: The objective of the present study was to develop a hydrodynamically balanced system for celecoxib as single-unit floating capsules and it was concluded that the release followed zero-order kinetics, as the correlation coefficient (R value) was higher for zero- order release.
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Emulsifying properties of gum kondagogu (Cochlospermum gossypium), a natural biopolymer
Ganga Modi Naidu Vegi,Ramakrishna Sistla,Palaniappan Srinivasan,Sashidhar Rao Beedu,Roop K. Khar,Prakash V. Diwan +5 more
TL;DR: In this article, the authors investigated the emulsifying properties of the natural biopolymer gum kondagogu (GKG) and found that the stabilisation of emulsions with GKG was due to mutual repulsion between electrical double layers of particles and adsorption of macromolecules on oil droplets.
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In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil.
Ziyaur Rahman,Ziyaur Rahman,Kanchan Kohli,Shuang Qing Zhang,Roop K. Khar,Mushir Ali,Naseem A. Charoo,Mohammad Tauseef,Areeg A. A. Shamsher,Noorullah Naqvi Mohammed,Michael A. Repka +10 more
TL;DR: In summary, Eudragit S‐100 coated alginate microspheres delivered 5‐FU to colonic tissues, with reduced systemic side‐effects, and a long‐term dosing study is required to ascertain the therapeutic benefits.
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High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats.
Ajeet Kumar Singh,Akash Chaurasiya,Gaurav K. Jain,Anshumali Awasthi,Dinesh P Asati,Gautam Mishra,Roop K. Khar,Rama Mukherjee +7 more
TL;DR: A sensitive, specific reversed-phase high performance liquid chromatographic (HPLC) method using ultraviolet detection was developed and validated for the analysis of bicalutamide (BCT) in rat blood plasma and it was concluded that the absorption of bICALutamide from SMEDDS was enhanced.