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Rosalyn Lang
Researcher at North Carolina Agricultural and Technical State University
Publications - 12
Citations - 314
Rosalyn Lang is an academic researcher from North Carolina Agricultural and Technical State University. The author has contributed to research in topics: Frameshift mutation & Genome-wide association study. The author has an hindex of 7, co-authored 12 publications receiving 231 citations.
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Journal ArticleDOI
Repeat expansions in the C9ORF72 gene contribute to Alzheimer's disease in Caucasians
Martin A. Kohli,Krista John-Williams,Ruchita Rajbhandary,Adam C. Naj,Patrice L. Whitehead,Kara Hamilton,Regina M. Carney,Clinton B. Wright,Elizabeth Crocco,Harry E. Gwirtzman,Rosalyn Lang,Gary W. Beecham,Gary W. Beecham,Eden R. Martin,Eden R. Martin,John R. Gilbert,John R. Gilbert,Michael Benatar,Gary W. Small,Deborah C. Mash,Goldie S. Byrd,Jonathan L. Haines,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance,Stephan Züchner,Stephan Züchner +25 more
TL;DR: The notion that large C9ORF72 expansions lead to a phenotypic spectrum of neurodegenerative disease including Alzheimer's disease including AD is supported.
Journal ArticleDOI
ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
Holly N. Cukier,Brian W. Kunkle,Badri N. Vardarajan,Sophie Rolati,Kara L. Hamilton-Nelson,Martin A. Kohli,Patrice L. Whitehead,Beth A. Dombroski,Derek J. Van Booven,Rosalyn Lang,Derek M. Dykxhoorn,Lindsay A. Farrer,Michael L. Cuccaro,Jeffery M. Vance,John R. Gilbert,Gary W. Beecham,Eden R. Martin,Regina M. Carney,Richard Mayeux,Gerard D. Schellenberg,Goldie S. Byrd,Jonathan L. Haines,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance +23 more
TL;DR: This common ABCA7 deletion could represent an ethnic-specific pathogenic alteration in AD and is predicted to result in a frameshift mutation that could interfere with protein function.
Journal ArticleDOI
African American Participation in Health-Related Research Studies: Indicators for Effective Recruitment
Rosalyn Lang,Vinaya Kelkar,Jennifer R. Byrd,Christopher L. Edwards,Margaret A. Pericak-Vance,Goldie S. Byrd +5 more
TL;DR: In this paper, the African American Alzheimer disease research study group at North Carolina A&T State University designed an in-person questionnaire and surveyed more than 700 African American adults on their willingness to participate in health-related research studies.
Journal ArticleDOI
Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk
Timothy J. Hohman,Jessica N. Cooke-Bailey,Christiane Reitz,Gyungah Jun,Adam C. Naj,Gary W. Beecham,Gary W. Beecham,Zhi Liu,Zhi Liu,Regina M. Carney,Regina M. Carney,Jeffrey M. Vance,Jeffrey M. Vance,Michael L. Cuccaro,Michael L. Cuccaro,Michael L. Cuccaro,Ruchita Rajbhandary,Ruchita Rajbhandary,Badri N. Vardarajan,Li-San Wang,Otto Valladares,Chiao-Feng Lin,Eric B. Larson,Eric B. Larson,Neill R. Graff-Radford,Denis A. Evans,Philip L. De Jager,Philip L. De Jager,Paul K. Crane,Paul K. Crane,Joseph D. Buxbaum,Jill R. Murrell,Towfique Raj,Towfique Raj,Nilufer Ertekin-Taner,Mark W. Logue,Clinton T. Baldwin,Robert C. Green,Lisa L. Barnes,Laura B. Cantwell,M. Daniele Fallin,Rodney C.P. Go,Patrick Griffith,Thomas O. Obisesan,Jennifer J. Manly,Kathryn L. Lunetta,M. Ilyas Kamboh,Oscar L. Lopez,David A. Bennett,John Hardy,Hugh C. Hendrie,Kathleen S. Hall,Alison Goate,Rosalyn Lang,Goldie S. Byrd,Walter A. Kukull,Tatiana Foroud,Lindsay A. Farrer,Eden R. Martin,Eden R. Martin,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Richard Mayeux,Jonathan L. Haines,Tricia A. Thornton-Wells +65 more
TL;DR: African‐American (AA) individuals have a higher risk for late‐onset Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA) and there likely are risk variants of higher frequency in AAs that have not been discovered.
Journal ArticleDOI
Relationship Between Depressive Symptoms and Cognition in Older, Non-demented African Americans
Jamie L. Hamilton,Adam M. Brickman,Rosalyn Lang,Goldie S. Byrd,Jonathan L. Haines,Margaret A. Pericak-Vance,Jennifer J. Manly +6 more
TL;DR: Controlling for age, education, reading level, and sex, African American older adults who endorsed more symptoms obtained significantly lower scores on measures of memory, language, processing speed, and executive functioning.