R
Rosella Mechelli
Researcher at Sapienza University of Rome
Publications - 49
Citations - 1811
Rosella Mechelli is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Multiple sclerosis & Population. The author has an hindex of 20, co-authored 45 publications receiving 1589 citations.
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Journal ArticleDOI
A “candidate-interactome” aggregate analysis of genome-wide association data in multiple sclerosis
Rosella Mechelli,Renato Umeton,Claudia Policano,Viviana Annibali,Giulia Coarelli,Vito A. G. Ricigliano,Danila Vittori,Arianna Fornasiero,Maria Chiara Buscarinu,Silvia Romano,Marco Salvetti,Giovanni Ristori +11 more
TL;DR: The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology, and also other viruses have a similar potential, though probably less relevant in epidemiological terms.
Journal ArticleDOI
CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis
Viviana Annibali,Giovanni Ristori,Daniela F. Angelini,Barbara Serafini,Rosella Mechelli,Stefania Cannoni,Silvia Romano,Andrea Paolillo,Hadi Abderrahim,Adamo Diamantini,Giovanna Borsellino,Francesca Aloisi,Luca Battistini,Marco Salvetti +13 more
TL;DR: Variations of CD161 expression on CD8(+) T cells identify a subset of lymphocytes with proinflammatory characteristics that have not been previously reported in multiple sclerosis and are likely to contribute to disease immunopathology.
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Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis
Daniela F. Angelini,Barbara Serafini,Eleonora Piras,Martina Severa,Eliana M. Coccia,Barbara Rosicarelli,Serena Ruggieri,Claudio Gasperini,Fabio Buttari,Diego Centonze,Rosella Mechelli,Marco Salvetti,Giovanna Borsellino,Francesca Aloisi,Luca Battistini +14 more
TL;DR: It is proposed that inability to control EBV infection during inactive MS could set the stage for intracerebral viral reactivation and disease relapse.
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Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study
Maria Chiara Buscarinu,Benedetta Cerasoli,Viviana Annibali,Claudia Policano,Luana Lionetto,Matilde Capi,Rosella Mechelli,Silvia Romano,Arianna Fornasiero,Gianluca Mattei,Eleonora Piras,Daniela F. Angelini,Luca Battistini,Maurizio Simmaco,Renato Umeton,Marco Salvetti,Giovanni Ristori +16 more
TL;DR: The relatively high proportion of IP changes in RR-MS patients seems to confirmed the work hypothesis and warrants more work to confirm the result on a larger sample, and to understand the implications for related immunological disturbances and intestinal microbiota alterations.
Journal ArticleDOI
Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood.
Roberta Calabrese,Michele Zampieri,Rosella Mechelli,Viviana Annibali,Tiziana Guastafierro,Fabio Ciccarone,Giulia Coarelli,Renato Umeton,Marco Salvetti,Paola Caiafa +9 more
TL;DR: Defective regulation of PAD2 in the periphery, without the immunological shelter of the blood–brain barrier, may contribute to the development of the autoimmune responses in MS.