R
Rui-An Wang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 12
Citations - 1156
Rui-An Wang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Kinase & Estrogen receptor. The author has an hindex of 10, co-authored 12 publications receiving 1111 citations. Previous affiliations of Rui-An Wang include Fourth Military Medical University.
Papers
More filters
Journal ArticleDOI
Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor
Abhijit Mazumdar,Rui-An Wang,Sandip K. Mishra,Liana Adam,Rozita Bagheri-Yarmand,Mahitosh Mandal,Ratna K. Vadlamudi,Rakesh Kumar +7 more
TL;DR: Results identify ER-mediated transcription as a nuclear target of MTA1 and indicate that HDAC complexes associated with the MTA1 corepressor may mediate ER transcriptional repression by HRG.
Journal ArticleDOI
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
Ratna K. Vadlamudi,Liana Adam,Rui-An Wang,Mahitosh Mandal,Diep Nguyen,Aysegul Sahin,Jonathan Chernoff,Mien Chie Hung,Rakesh Kumar +8 more
TL;DR: This study provides evidence to suggest a close correlation between the status of Pak1 kinase activity and base-line invasiveness of human breast cancer cells and breast tumor grades and develops human epithelial MCF-7 clones that overexpressed the kinase-active T423E Pak1 mutant under an inducible tetracycline promoter.
Journal ArticleDOI
P21-Activated Kinase 1 Regulation of Estrogen Receptor-α Activation Involves Serine 305 Activation Linked with Serine 118 Phosphorylation
Suresh K. Rayala,Amjad H. Talukder,Seetharaman Balasenthil,Robbin Tharakan,Christopher J. Barnes,Rui-An Wang,C. Marcelo Aldaz,Sohaib A. Khan,Rakesh Kumar +8 more
TL;DR: It is suggested that Pak1 signaling-dependent activation of ER-S305 leads to an enhanced S118 phosphorylation presumably due to a conformational change, and such structural modifications may participate in the development of tamoxifen resistance.
Journal ArticleDOI
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
TL;DR: Results showed that in a transgenic mouse model, overexpression of catalytically active Pak1 leads to the development of malignant mammary tumors and to a variety of other breast lesions, including focal solid nodules, ductal hyperplasia, and mini-intraductal neoplasm and adenoma.
Journal ArticleDOI
MTA1 promotes STAT3 transcription and pulmonary metastasis in breast cancer
Suresh B. Pakala,Suresh K. Rayala,Rui-An Wang,Kazufumi Ohshiro,Prakriti Mudvari,Sirigiri Divijendra Natha Reddy,Yi Zheng,Ricardo A. Pires,Sandra Casimiro,M. Radhakrishna Pillai,Luis Costa,Rakesh Kumar +11 more
TL;DR: It is found that MTA1 acts as a mandatory modifier of breast-to-lung metastasis without effects on primary tumor formation and an essential modifying role of the physiologic level of MTA1 in supporting pulmonary metastasis of breast cancer.