Cynthia Cowdrey

TL;DR: It is demonstrated that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors.

TL;DR: Functional assays in different SHH-MB xenograft models demonstrated that SHh-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant.

TL;DR: The results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-Renewing cell types expressing a range of markers of forebrain lineage.

TL;DR: This paper identified LIN28A as a highly specific marker for embryonal tumor with multilayered rosettes (ETMR), which is a highly aggressive embryonal CNS tumor which almost exclusively affects infants and is associated with a dismal prognosis.

TL;DR: The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors.