R
Ryan D. Hernandez
Researcher at McGill University
Publications - 105
Citations - 32798
Ryan D. Hernandez is an academic researcher from McGill University. The author has contributed to research in topics: Population & Genetic variation. The author has an hindex of 44, co-authored 102 publications receiving 24574 citations. Previous affiliations of Ryan D. Hernandez include Rockefeller University & Johns Hopkins University.
Papers
More filters
Posted ContentDOI
An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses
BH Penn,Zoe Netter,Jeffrey R. Johnson,John Von Dollen,Gwendolyn M. Jang,Tasha L. Johnson,Yamini M. Ohol,C Maher,Samantha L. Bell,Kristina M. Geiger,X Du,Alex Choi,Trevor J Parry,M Naramura,Curtis Chen,S Jaeger,Michael Shales,Daniel A. Portnoy,Ryan D. Hernandez,Laurent Coscoy,Jeffery S. Cox,Nevan J. Krogan +21 more
TL;DR: It is discovered that an lpqN Mtb mutant is attenuated in macrophages, but growth is restored when CBL is removed, indicating that CBL regulates cell-intrinsic polarization between anti-bacterial and anti-viral immunity.
Posted ContentDOI
Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex
M. Elgart,Matthew Goodman,Matthew Goodman,Carmen R. Isasi,Han Chen,P. De Vries,Huichun Xu,Ani Manichaikul,Xuejiang Guo,Nora Franceschini,Bruce M. Psaty,Stephen S. Rich,Jerome I. Rotter,Donald M. Lloyd-Jones,Myriam Fornage,Adolfo Correa,Nancy L. Heard-Costa,Vasan S. Ramachandran,Ryan D. Hernandez,Robert C. Kaplan,Robert C. Kaplan,Susan Redline,Susan Redline,Tamar Sofer,Tamar Sofer +24 more
TL;DR: In this article, the authors developed closed-form estimators of genetic and environmental correlation coefficients and applied them to estimate over 4,000 GA and environmental correlations between multiple phenotypes in a diverse sample from the Trans-Omics in Precision Medicine program.
Journal ArticleDOI
Correction: Human demographic history has amplified the effects of background selection across the genome.
TL;DR: This research presents a novel probabilistic procedure that allows for direct measurement of the response of the immune system to earthquake-triggered landsliding.
Posted ContentDOI
De novo mutations across 1,465 diverse genomes reveal novel mutational insights and reductions in the Amish founder population
Michael D. Kessler,Douglas Loesch,James A. Perry,Nancy L. Heard-Costa,Brian E. Cade,Brian E. Cade,Heming Wang,Heming Wang,Michelle Daya,John Ziniti,Soma Datta,Juan C. Celedón,Manuel E. Soto-Quiros,Lydiana Avila,Scott T. Weiss,Scott T. Weiss,Kathleen C. Barnes,Susan Redline,Susan Redline,Susan Redline,Ramachandran S. Vasan,Andrew D. Johnson,Rasika A. Mathias,Ryan D. Hernandez,James G. Wilson,Deborah A. Nickerson,Gonçalo R. Abecasis,Sharon R. Browning,Sebastian Zöllner,Jeffrey R. O'Connell,Braxton D. Mitchell,Braxton D. Mitchell,Timothy D. O’Connor +32 more
TL;DR: It is demonstrated that the human single nucleotide mutation rate is similar across numerous human ancestries and populations, and a reduced mutation rate in the Amish founder population is discovered, which shows that mutation rates can shift rapidly.
Posted ContentDOI
Genomic characterization of serial-passaged Ebola virus in a boa constrictor cell line
Greg Fedewa,Sheli R. Radoshitzky,Xiăolì Chī,Lián Dǒng,Melissa L. Spear,Nicolas Strauli,Mark D. Stenglein,Ryan D. Hernandez,Peter B. Jahrling,Jens H. Kuhn,Joseph L. DeRisi +10 more
TL;DR: Serially passaged EBOV and a distantly related filovirus, Marburg virus, in the boa constrictor kidney cell line, JK, and characterized viral growth and mutational frequency by sequencing suggest different filoviruses may have a more diverse natural host spectra than previously thought.