J
John Ziniti
Researcher at Brigham and Women's Hospital
Publications - 32
Citations - 1837
John Ziniti is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 17, co-authored 28 publications receiving 1627 citations. Previous affiliations of John Ziniti include Harvard University.
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Journal ArticleDOI
Variants in FAM13A are associated with chronic obstructive pulmonary disease
Michael H. Cho,Nadia Boutaoui,Barbara J. Klanderman,Jody S. Sylvia,John Ziniti,Craig P. Hersh,Dawn L. DeMeo,Gary M. Hunninghake,Augusto L. Litonjua,David Sparrow,David Sparrow,Christoph Lange,Sungho Won,James Murphy,Terri H. Beaty,Elizabeth A. Regan,Barry J. Make,John E. Hokanson,James D. Crapo,Xiangyang Kong,Wayne Anderson,Ruth Tal-Singer,David A. Lomas,Per Bakke,Amund Gulsvik,Sreekumar G. Pillai,Sreekumar G. Pillai,Edwin K. Silverman +27 more
TL;DR: A new susceptibility locus at 4q22.1 in FAM13A is identified and replicated in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function.
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Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Michael H. Cho,Merry-Lynn McDonald,Xiaobo Zhou,Manuel Mattheisen,Manuel Mattheisen,Peter J. Castaldi,Craig P. Hersh,Dawn L. DeMeo,Jody S. Sylvia,John Ziniti,Nan M. Laird,Christoph Lange,Augusto A. Litonjua,David Sparrow,David Sparrow,Richard Casaburi,R. Graham Barr,Elizabeth A. Regan,Barry J. Make,John E. Hokanson,Sharon M. Lutz,Tanda Murray Dudenkov,Homayoon Farzadegan,Jacqueline B. Hetmanski,Ruth Tal-Singer,David A. Lomas,Per Bakke,Per Bakke,Amund Gulsvik,Amund Gulsvik,James D. Crapo,Edwin K. Silverman,Terri H. Beaty +32 more
TL;DR: In this article, the authors identified risk loci for moderate to severe and severe COPD with data from several cohort studies and combined results in a joint meta-analysis (threshold for significance p −8 ).
Journal ArticleDOI
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
Michael H. Cho,Peter J. Castaldi,Emily S. Wan,Mateusz Siedlinski,Craig P. Hersh,Dawn L. DeMeo,Blanca E. Himes,Jody S. Sylvia,Barbara J. Klanderman,John Ziniti,Christoph Lange,Augusto A. Litonjua,David Sparrow,David Sparrow,Elizabeth A. Regan,Barry J. Make,John E. Hokanson,Tanda Murray,Jacqueline B. Hetmanski,Sreekumar G. Pillai,Xiangyang Kong,Wayne H. Anderson,Ruth Tal-Singer,David A. Lomas,Harvey O. Coxson,Lisa D. Edwards,William MacNee,Jørgen Vestbo,Julie C. Yates,Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Courtney Crim,Stephen I. Rennard,Emiel F.M. Wouters,Per Bakke,Amund Gulsvik,James D. Crapo,Terri H. Beaty,Edwin K. Silverman +39 more
TL;DR: A new genome-wide significant locus on chromosome 19q13, which includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior is identified.
Journal ArticleDOI
Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART)
Joanne E. Sordillo,Yanjiao Zhou,Michael J. McGeachie,John Ziniti,Nancy E. Lange,Nancy Laranjo,Jessica Rabe Savage,Vincent J. Carey,George T. O'Connor,Megan Sandel,Robert C. Strunk,Leonard B. Bacharier,Robert S. Zeiger,Scott T. Weiss,George M. Weinstock,Diane R. Gold,Augusto A. Litonjua +16 more
TL;DR: The findings presented here suggest that race, mode of delivery, breast‐feeding, and cord blood vitamin D levels are associated with infant gut microbiome composition, with possible long‐term implications for immune system modulation and asthma/allergic disease incidence.
Journal ArticleDOI
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
Amy Murphy,Jen-Hwa Chu,Mousheng Xu,Vincent J. Carey,Ross Lazarus,Andrew H. Liu,Stanley J. Szefler,Robert C. Strunk,Karen DeMuth,Mario Castro,Nadia N. Hansel,Gregory B. Diette,Becky M. Vonakis,N. Franklin Adkinson,Barbara J. Klanderman,Jody Senter-Sylvia,John Ziniti,Christoph Lange,Christoph Lange,Tomi Pastinen,Benjamin A. Raby +20 more
TL;DR: Genome-wide association studies of human gene expression promise to identify functional regulatory genetic variation that contributes to phenotypic diversity, but it is unclear how useful this approach will be for the identification of disease-susceptibility variants.