R
Ryan D. Hernandez
Researcher at McGill University
Publications - 105
Citations - 32798
Ryan D. Hernandez is an academic researcher from McGill University. The author has contributed to research in topics: Population & Genetic variation. The author has an hindex of 44, co-authored 102 publications receiving 24574 citations. Previous affiliations of Ryan D. Hernandez include Rockefeller University & Johns Hopkins University.
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Journal ArticleDOI
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.
Daniel Taliun,Daniel N. Harris,Michael D. Kessler,Jedidiah Carlson,Jedidiah Carlson,Zachary A. Szpiech,Raul Torres,Sarah A Gagliano Taliun,André Corvelo,Stephanie M. Gogarten,Hyun Min Kang,Achilleas N. Pitsillides,Jonathon LeFaive,Seung-been Lee,Xiaowen Tian,Brian L. Browning,Sayantan Das,Anne-Katrin Emde,Wayne E. Clarke,Douglas Loesch,Amol C. Shetty,Thomas W. Blackwell,Albert V. Smith,Quenna Wong,Xiaoming Liu,Matthew P. Conomos,Dean Bobo,François Aguet,Christine M. Albert,Alvaro Alonso,Kristin G. Ardlie,Dan E. Arking,Stella Aslibekyan,Paul L. Auer,John Barnard,R. Graham Barr,Lucas Barwick,Lewis C. Becker,Rebecca L. Beer,Emelia J. Benjamin,Lawrence F. Bielak,John Blangero,Michael Boehnke,Donald W. Bowden,Jennifer A. Brody,Esteban G. Burchard,Brian E. Cade,Brian E. Cade,James F. Casella,Brandon Chalazan,Daniel I. Chasman,Daniel I. Chasman,Yii-Der Ida Chen,Michael H. Cho,Seung Hoan Choi,Mina K. Chung,Mina K. Chung,Mina K. Chung,Clary B. Clish,Adolfo Correa,Joanne E. Curran,Brian Custer,Dawood Darbar,Michelle Daya,Mariza de Andrade,Dawn L. DeMeo,Susan K. Dutcher,Patrick T. Ellinor,Leslie S. Emery,Celeste Eng,Diane Fatkin,Diane Fatkin,Diane Fatkin,Tasha E. Fingerlin,Lukas Forer,Myriam Fornage,Nora Franceschini,Christian Fuchsberger,Stephanie M. Fullerton,Soren Germer,Mark T. Gladwin,Daniel J. Gottlieb,Daniel J. Gottlieb,Xiuqing Guo,Michael E. Hall,Jiang He,Nancy L. Heard-Costa,Susan R. Heckbert,Marguerite R. Irvin,Jill M. Johnsen,Andrew D. Johnson,Robert C. Kaplan,Sharon L.R. Kardia,Tanika N. Kelly,Shannon Kelly,Eimear E. Kenny,Douglas P. Kiel,Robert Klemmer,Barbara A. Konkle,Charles Kooperberg,Anna Köttgen,Anna Köttgen,Leslie A. Lange,Jessica Lasky-Su,Daniel Levy,Daniel Levy,Xihong Lin,Keng-Han Lin,Chunyu Liu,Ruth J. F. Loos,Lori Garman,Robert E. Gerszten,Steven A. Lubitz,Kathryn L. Lunetta,Angel C.Y. Mak,Ani Manichaikul,Alisa K. Manning,Alisa K. Manning,Rasika A. Mathias,David D. McManus,Stephen T. McGarvey,James B. Meigs,Deborah A. Meyers,Julie L. Mikulla,Mollie A. Minear,Braxton D. Mitchell,Braxton D. Mitchell,Sanghamitra Mohanty,May E. Montasser,Courtney G. Montgomery,Alanna C. Morrison,Joanne M. Murabito,Andrea Natale,Pradeep Natarajan,Sarah C. Nelson,Kari E. North,Jeffrey R. O'Connell,Nicholette D. Palmer,Nathan Pankratz,Gina M. Peloso,Patricia A. Peyser,Jacob Pleiness,Wendy S. Post,Bruce M. Psaty,D. C. Rao,Susan Redline,Susan Redline,Alexander P. Reiner,Alexander P. Reiner,Dan M. Roden,Jerome I. Rotter,Ingo Ruczinski,Chloé Sarnowski,Sebastian Schoenherr,David A. Schwartz,Jeong-Sun Seo,Sudha Seshadri,Vivien A. Sheehan,Wayne Huey-Herng Sheu,M. Benjamin Shoemaker,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Jennifer A. Smith,Nona Sotoodehnia,Adrienne M. Stilp,Weihong Tang,Kent D. Taylor,Marilyn J. Telen,Timothy A. Thornton,Russell P. Tracy,David Van Den Berg,Ramachandran S. Vasan,Karine A. Viaud-Martinez,Scott I. Vrieze,Daniel E. Weeks,Bruce S. Weir,Scott T. Weiss,Lu-Chen Weng,Cristen J. Willer,Yingze Zhang,Xutong Zhao,Donna K. Arnett,Allison E. Ashley-Koch,Kathleen C. Barnes,Eric Boerwinkle,Eric Boerwinkle,Stacey Gabriel,Richard A. Gibbs,Kenneth Rice,Stephen S. Rich,Edwin K. Silverman,Pankaj Qasba,Weiniu Gan,George J. Papanicolaou,Deborah A. Nickerson,Sharon R. Browning,Michael C. Zody,Sebastian Zöllner,James G. Wilson,L. Adrienne Cupples,Cathy C. Laurie,Cashell E. Jaquish,Ryan D. Hernandez,Timothy D. O’Connor,Gonçalo R. Abecasis +205 more
TL;DR: The Trans-Omics for Precision Medicine (TOPMed) project as discussed by the authors aims to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treatment and prevention of these diseases.
Journal ArticleDOI
Natural selection on protein-coding genes in the human genome
Carlos Bustamante,Adi Fledel-Alon,Scott Williamson,Rasmus Nielsen,Rasmus Nielsen,Melissa Todd Hubisz,Stephen Glanowski,David M. Tanenbaum,Thomas J. White,John J. Sninsky,Ryan D. Hernandez,Daniel Civello,Mark Raymond Adams,Michele Cargill,Andrew G. Clark +14 more
TL;DR: Comparisons of DNA polymorphism within species to divergence between species enables the discovery of molecular adaptation in evolutionarily constrained genes as well as the differentiation of weak from strong purifying selection, and finds strong evidence that natural selection has shaped the recent molecular evolution of the authors' species.
Journal ArticleDOI
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Dara G. Torgerson,Dara G. Torgerson,Elizabeth J. Ampleford,Grace Y. Chiu,W. James Gauderman,Christopher R. Gignoux,Penelope E. Graves,Blanca E. Himes,Albert M. Levin,Rasika A. Mathias,Dana B. Hancock,Dana B. Hancock,Dana B. Hancock,James W. Baurley,Celeste Eng,Debra A. Stern,Juan C. Celedón,Nicholas Rafaels,Daniel Capurso,David V. Conti,Lindsey A. Roth,Manuel Soto-Quiros,Alkis Togias,Xingnan Li,Rachel A. Myers,Isabelle Romieu,Isabelle Romieu,David Van Den Berg,Donglei Hu,Nadia N. Hansel,Ryan D. Hernandez,Elliott Israel,Muhammad T. Salam,Joshua Galanter,Pedro C. Avila,Lydiana Avila,Jose R. Rodriquez-Santana,R. Chapela,William Rodríguez-Cintrón,Gregory B. Diette,N. Franklin Adkinson,Rebekah A. Abel,K. Ross,Min Shi,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Vito J. Mantese,Serpil C. Ezurum,Liming Liang,Ingo Ruczinski,Jean G. Ford,Scott Huntsman,Kian Fan Chung,Hita Vora,Xia Li,William J. Calhoun,Mario Castro,Juan José Luis Sienra-Monge,Blanca Estela Del Río-Navarro,Klaus A. Deichmann,Andrea Heinzmann,Sally E. Wenzel,William W. Busse,William W. Busse,James E. Gern,Robert F. Lemanske,Terri H. Beaty,Eugene R. Bleecker,Benjamin A. Raby,Deborah A. Meyers,Stephanie J. London,Frank D. Gilliland,Esteban G. Burchard,Fernando D. Martinez,Scott T. Weiss,L. Keoki Williams,Kathleen C. Barnes,Carole Ober,Dan L. Nicolae +79 more
TL;DR: The results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
Journal ArticleDOI
Genome-Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds
Richard A. Gibbs,Jeremy F. Taylor,Curtis P. Van Tassell,William Barendse,William Barendse,Kellye Eversole,Clare A. Gill,Ronnie D. Green,Debora L. Hamernik,Steven M. Kappes,Sigbjørn Lien,Lakshmi K. Matukumalli,Lakshmi K. Matukumalli,John C. McEwan,Lynne V. Nazareth,Robert D. Schnabel,George M. Weinstock,David A. Wheeler,Paolo Ajmone-Marsan,Paul Boettcher,Alexandre Rodrigues Caetano,José Fernando Garcia,José Fernando Garcia,Olivier Hanotte,Paola Mariani,Loren C. Skow,Tad S. Sonstegard,John L. Williams,John L. Williams,Boubacar Diallo,Lemecha Hailemariam,Mário Luiz Martinez,C. A. Morris,Luiz Otávio Campos da Silva,Richard J. Spelman,Woudyalew Mulatu,Keyan Zhao,Colette A. Abbey,Morris Agaba,Flábio R. Araújo,Rowan J. Bunch,Rowan J. Bunch,James O. Burton,C. Gorni,Hanotte Olivier,Blair E. Harrison,Blair E. Harrison,Bill Luff,Marco Antonio Machado,Joel Mwakaya,Graham Plastow,Warren Sim,Warren Sim,Timothy P. L. Smith,Merle B Thomas,Merle B Thomas,Alessio Valentini,Paul D. Williams,James E. Womack,John Woolliams,Yue Liu,Xiang Qin,Kim C. Worley,Chuan Gao,Huaiyang Jiang,Stephen S. Moore,Yanru Ren,Xingzhi Song,Carlos Bustamante,Ryan D. Hernandez,Donna M. Muzny,Shobha Patil,Anthony San Lucas,Qing Fu,Matthew Peter Kent,Richard Vega,Aruna Matukumalli,Sean McWilliam,Sean McWilliam,Gert Sclep,Katarzyna Bryc,Jung-Woo Choi,Hong Gao,John J. Grefenstette,Brenda M. Murdoch,Alessandra Stella,Rafael Villa-Angulo,Mark G. Wright,Jan Aerts,Jan Aerts,Oliver C. Jann,Riccardo Negrini,Michael E. Goddard,Michael E. Goddard,Ben J. Hayes,Daniel G. Bradley,Marcos V.B. da Silva,Marcos V.B. da Silva,Lilian P.L. Lau,George E. Liu,David J. Lynn,David J. Lynn,Francesca Panzitta,Ken G. Dodds +103 more
TL;DR: Data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation.
Journal ArticleDOI
Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome
Adam R. Boyko,Scott Williamson,Amit Indap,Jeremiah D. Degenhardt,Ryan D. Hernandez,Kirk E. Lohmueller,Mark Raymond Adams,Steffen Schmidt,John J. Sninsky,Shamil R. Sunyaev,Thomas J. White,Rasmus Nielsen,Andrew G. Clark,Carlos Bustamante +13 more
TL;DR: The analysis predicts that many of the alleles identified via whole-genome association mapping may be selectively neutral or (formerly) positively selected, implying that deleterious genetic variation affecting disease phenotype may be missed by this widely used approach for mapping genes underlying complex traits.