R
Ryota Ebata
Researcher at Chiba University
Publications - 26
Citations - 748
Ryota Ebata is an academic researcher from Chiba University. The author has contributed to research in topics: Kawasaki disease & Genome-wide association study. The author has an hindex of 10, co-authored 23 publications receiving 582 citations.
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Journal ArticleDOI
A genome-wide association study identifies three new risk loci for Kawasaki disease
Yoshihiro Onouchi,Kouichi Ozaki,Jane C. Burns,Jane C. Burns,Chisato Shimizu,Chisato Shimizu,Masaru Terai,Hiromichi Hamada,Takafumi Honda,Hiroyuki Suzuki,Tomohiro Suenaga,Takashi Takeuchi,Norishige Yoshikawa,Yoichi Suzuki,Kumi Yasukawa,Ryota Ebata,Kouji Higashi,Tsutomu Saji,Yasushi Kemmotsu,Shinichi Takatsuki,Kazunobu Ouchi,Fumio Kishi,Tetsushi Yoshikawa,Toshiro Nagai,Kunihiro Hamamoto,Yoshitake Sato,Akihito Honda,Hironobu Kobayashi,Junichi Sato,Shoichi Shibuta,Masakazu Miyawaki,Ko Oishi,Hironobu Yamaga,Noriyuki Aoyagi,Seiji Iwahashi,Ritsuko Miyashita,Yuji Murata,Kumiko Sasago,Atsushi Takahashi,Naoyuki Kamatani,Michiaki Kubo,Tatsuhiko Tsunoda,Akira Hata,Yusuke Nakamura,Toshihiro Tanaka +44 more
TL;DR: A genome-wide association study of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki Disease and 3,379 controls genotyped at 473,803 SNPs provides new insights into the pathogenesis and pathophysiology of Kaw Osaka disease.
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Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial
Hiromichi Hamada,Hiroyuki Suzuki,Yoshihiro Onouchi,Ryota Ebata,Masaru Terai,Shigeto Fuse,Yoshitomo Okajima,Shunji Kurotobi,Katsuki Hirai,Takashi Soga,Yukiko Ishiguchi,Yoshiaki Okuma,Nobuyuki Takada,Masaaki Yanai,Junichi Sato,Mami Nakayashiro,Mamoru Ayusawa,Eiichi Yamamoto,Yuichi Nomura,Yuya Hashimura,Kazunobu Ouchi,Hiroshi Masuda,Shinichi Takatsuki,Keiichi Hirono,Tadashi Ariga,Takashi Higaki,Akio Otsuki,Moe Terauchi,Reiko Aoyagi,Takatoshi Sato,Yasuhisa Fujii,Tadami Fujiwara,Hideki Hanaoka,Akira Hata,Takafumi Honda,Kumi Yasukawa,Nishihara Takahiro,Hideoki Yajima,Hideyasu Ooto,You Umeda,Takashi Takeuchi,Tomohiro Suenaga,Nobuyuki Kakimoto,Masahiro Kamada,Shinichi Suwabe,Yasushi Ueno,Natsuko Nishi,Yuuko Saito,Yutaka Kitani,Taisuke Nabeshima,Kiyotaka Takefuta,Takahiro Nakamura,Akiko Komori,Masataka Kato,Naoki Saito,Kentaro Okunushi,Hironobu Kobayashi,Takeshi Nakano,Kiminori Masuda,Hirotaka Minami,Takamichi Uchiyama,You Okizuka,Naoki Ohno,Satoko Ogita,Hiroshi Ono,Akira Ishiguro,Tsutomu Saji,Fukiko Ichida,Sayaka Ozawa,Atsuhito Takeda,Gaku Izumi,Michiko Hanawa +71 more
TL;DR: Combined primary therapy with IVIG and ciclosporin was safe and effective for favourable coronary artery outcomes in Kawasaki disease patients who were predicted to be unresponsive to IVIG.
Journal ArticleDOI
ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.
Yoshihiro Onouchi,Yoichi Suzuki,Hiroyuki Suzuki,Masaru Terai,Kumi Yasukawa,Hiromichi Hamada,Tomohiro Suenaga,Takafumi Honda,Akihito Honda,H Kobayashi,Takashi Takeuchi,Norishige Yoshikawa,J Sato,Shoichi Shibuta,Masakazu Miyawaki,Ko Oishi,Hironobu Yamaga,Noriyuki Aoyagi,Seiji Iwahashi,Ritsuko Miyashita,Y Murata,Ryota Ebata,Kouji Higashi,Kouichi Ozaki,Kumiko Sasago,Toshihiro Tanaka,Akira Hata +26 more
TL;DR: The findings strongly suggest the existence of genetic factors affecting patients’ responses to treatment and the risk for cardiac complications, and provide clues toward understanding the pathophysiology of KD inflammation.
Journal ArticleDOI
Elevated granulocyte colony-stimulating factor levels predict treatment failure in patients with Kawasaki disease.
TL;DR: Findings suggest that polycythemia rubra vera 1 and granulocyte colony-stimulating factor levels may be good biomarkers for predicting response to IVIG in patients with KD.
Journal ArticleDOI
Nationwide Survey of Patients With Giant Coronary Aneurysm Secondary to Kawasaki Disease 1999–2010 in Japan
Ryuji Fukazawa,Tohru Kobayashi,Masashi Mikami,Tsutomu Saji,Kenji Hamaoka,Hitoshi Kato,Hiroyuki Suzuki,Etsuko Tsuda,Mamoru Ayusawa,Masaru Miura,Ryota Ebata,Tomio Kobayashi,Mayumi Yashiro,Shunichi Ogawa +13 more
TL;DR: Severe cardiac events are likely to occur within 2 years from onset of Kawasaki disease, while no deaths occurred beyond this time, Hence, careful monitoring is needed especially for the first 2 years.