H
Hironobu Yamaga
Publications - 6
Citations - 532
Hironobu Yamaga is an academic researcher. The author has contributed to research in topics: Kawasaki disease & Cyclosporin a. The author has an hindex of 5, co-authored 5 publications receiving 465 citations.
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Journal ArticleDOI
A genome-wide association study identifies three new risk loci for Kawasaki disease
Yoshihiro Onouchi,Kouichi Ozaki,Jane C. Burns,Jane C. Burns,Chisato Shimizu,Chisato Shimizu,Masaru Terai,Hiromichi Hamada,Takafumi Honda,Hiroyuki Suzuki,Tomohiro Suenaga,Takashi Takeuchi,Norishige Yoshikawa,Yoichi Suzuki,Kumi Yasukawa,Ryota Ebata,Kouji Higashi,Tsutomu Saji,Yasushi Kemmotsu,Shinichi Takatsuki,Kazunobu Ouchi,Fumio Kishi,Tetsushi Yoshikawa,Toshiro Nagai,Kunihiro Hamamoto,Yoshitake Sato,Akihito Honda,Hironobu Kobayashi,Junichi Sato,Shoichi Shibuta,Masakazu Miyawaki,Ko Oishi,Hironobu Yamaga,Noriyuki Aoyagi,Seiji Iwahashi,Ritsuko Miyashita,Yuji Murata,Kumiko Sasago,Atsushi Takahashi,Naoyuki Kamatani,Michiaki Kubo,Tatsuhiko Tsunoda,Akira Hata,Yusuke Nakamura,Toshihiro Tanaka +44 more
TL;DR: A genome-wide association study of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki Disease and 3,379 controls genotyped at 473,803 SNPs provides new insights into the pathogenesis and pathophysiology of Kaw Osaka disease.
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Cyclosporin A treatment for Kawasaki disease refractory to initial and additional intravenous immunoglobulin.
Hiroyuki Suzuki,Masaru Terai,Hiromichi Hamada,Takafumi Honda,Tomohiro Suenaga,Takashi Takeuchi,Norishige Yoshikawa,Shoichi Shibuta,Masakazu Miyawaki,Ko Oishi,Hironobu Yamaga,Noriyuki Aoyagi,Seiji Iwahashi,Ritsuko Miyashita,Yoshihiro Onouchi,Kumiko Sasago,Yoichi Suzuki,Akira Hata +17 more
TL;DR: CyA treatment is considered safe and well tolerated, and a promising option for patients with refractory Kawasaki disease, and further investigations will be needed to clarify optimal dose, safety, and timing of CyA treatment.
Journal ArticleDOI
ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.
Yoshihiro Onouchi,Yoichi Suzuki,Hiroyuki Suzuki,Masaru Terai,Kumi Yasukawa,Hiromichi Hamada,Tomohiro Suenaga,Takafumi Honda,Akihito Honda,H Kobayashi,Takashi Takeuchi,Norishige Yoshikawa,J Sato,Shoichi Shibuta,Masakazu Miyawaki,Ko Oishi,Hironobu Yamaga,Noriyuki Aoyagi,Seiji Iwahashi,Ritsuko Miyashita,Y Murata,Ryota Ebata,Kouji Higashi,Kouichi Ozaki,Kumiko Sasago,Toshihiro Tanaka,Akira Hata +26 more
TL;DR: The findings strongly suggest the existence of genetic factors affecting patients’ responses to treatment and the risk for cardiac complications, and provide clues toward understanding the pathophysiology of KD inflammation.
Journal ArticleDOI
Variations in ORAI1 Gene Associated with Kawasaki Disease.
Yoshihiro Onouchi,Ryuji Fukazawa,Kenichiro Yamamura,Hiroyuki Suzuki,Nobuyuki Kakimoto,Tomohiro Suenaga,Takashi Takeuchi,Hiromichi Hamada,Takafumi Honda,Kumi Yasukawa,Masaru Terai,Ryota Ebata,Kouji Higashi,Tsutomu Saji,Yasushi Kemmotsu,Shinichi Takatsuki,Kazunobu Ouchi,Fumio Kishi,Tetsushi Yoshikawa,Toshiro Nagai,Kunihiro Hamamoto,Yoshitake Sato,Akihito Honda,Hironobu Kobayashi,Junichi Sato,Shoichi Shibuta,Masakazu Miyawaki,Ko Oishi,Hironobu Yamaga,Noriyuki Aoyagi,Megumi Yoshiyama,Ritsuko Miyashita,Yuji Murata,Akihiro Fujino,Kouichi Ozaki,Tomisaku Kawasaki,Jun Abe,Mitsuru Seki,Tohru Kobayashi,Hirokazu Arakawa,Shunichi Ogawa,Toshiro Hara,Akira Hata,Toshihiro Tanaka +43 more
TL;DR: Data indicate that ORAI1 gene variations are associated with KD and may suggest the potential importance of the Ca(2+)/NFAT pathway in the pathogenesis of this disorder.
Journal ArticleDOI
Inflammatory cytokine profiles during Cyclosporin treatment for immunoglobulin-resistant Kawasaki disease
Hiromichi Hamada,Hiroyuki Suzuki,Jun Abe,Yoichi Suzuki,Tomohiro Suenaga,Takashi Takeuchi,Norishige Yoshikawa,Shoichi Shibuta,Masakazu Miyawaki,Ko Oishi,Hironobu Yamaga,Noriyuki Aoyagi,Seiji Iwahashi,Ritsuko Miyashita,Takafumi Honda,Yoshihiro Onouchi,Masaru Terai,Akira Hata +17 more
TL;DR: CsA treatment effectively reduced the persisting serum inflammatory cytokines in most of the IVIG-resistant KD patients, implying a mechanism explaining the effects of CsA.