S Anand Trip

TL;DR: A case series of 43 patients with neurological complications of SARS-CoV-2 infection includes encephalopathies, encephalitis, acute disseminated encephalomyelitis with haemorrhagic change, transverse myelitis, ischaemic stroke, and Guillain-Barré syndrome.

TL;DR: This study has demonstrated functionally relevant changes indicative of axonal loss and retinal ganglion cell loss in the RNFL and macula, respectively, after optic neuritis, and this noninvasive RNFL imaging technique could be used in trials of experimental treatments that aim to protect optic nerves from axonal losses.

TL;DR: There are significant global reductions in RNFLT and macular volume in the eyes of secondary progressive sclerosis patients not previously affected by ON, but not in primary progressive MS patients, compared with controls, which may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve.

TL;DR: It is suggested that axonal loss contributes to optic nerve atrophy following a single attack of optic neuritis, and axonal Loss due to other post-inflammatory brain lesions is likely to contribute to the global MRI measure of brain atrophy in multiple sclerosis.

TL;DR: It is suggested that optic nerve DT-MRI measures provide an indication of the structural integrity of axons.