S. Courtney Frasch

TL;DR: It is demonstrated here that calreticulin acts as a second general recognition ligand by binding and activating LDL-receptor-related protein (LRP) on the engulfing cell, which creates an environment where "don't eat me" signals are rendered inactive and "eat me" signalling signals congregate together and signal for removal.

TL;DR: It is still not clear which receptors mediate PS recognition on apoptotic cells; however, several interesting candidates have been proposed and a novel activity expressed on macrophages stimulated with digestible particles such as β-glucan is proposed.

TL;DR: It is suggested that Bax is regulated by phosphorylation of Ser184 in an Akt-dependent manner and thatosphorylation inhibits Bax effects on the mitochondria by maintaining the protein in the cytoplasm, heterodimerized with antiapoptotic Bcl-2 family members.

TL;DR: Findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3, which in turn activates p38alpha MAPk, ultimately regulating adhesion, NF-kappaB activation, enhanced gene expression of TNF-alpha, and regulation of T NF-alpha synthesis.

TL;DR: This review summarizes the current knowledge of the multiple factors that modulate macrophage efferocytic ability and highlights emerging therapeutic targets with significant potential for limiting chronic inflammation.