Kathleen A. McPhillips

TL;DR: It is demonstrated here that calreticulin acts as a second general recognition ligand by binding and activating LDL-receptor-related protein (LRP) on the engulfing cell, which creates an environment where "don't eat me" signals are rendered inactive and "eat me" signalling signals congregate together and signal for removal.

TL;DR: It is shown that lovastatin increased efferocytosis in vitro in an 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase-dependent manner, and suggest that statins may play an important therapeutic role in diseases where effercytosis is impaired and inflammation is dysregulated.

TL;DR: SP-A and SP-D tonically inhibit alveolar macrophage phagocytosis by binding SIRP alpha, which is essential for the resolution of acute pulmonary inflammation.

TL;DR: Findings support the hypothesis that impaired PS exposure on dying cells results in defective macrophage programming, with consequent efferocytic impairment, which has important implications in understanding the underlying cause of enhanced inflammation in CGD.

TL;DR: These studies demonstrate that P. aeruginosa can manipulate the inflammatory microenvironment through inhibition of apoptotic cell engulfment, and suggest potential strategies to limit pulmonary inflammation in cystic fibrosis.