S
Sabine Hellwig
Researcher at University of Freiburg
Publications - 64
Citations - 2585
Sabine Hellwig is an academic researcher from University of Freiburg. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 20, co-authored 53 publications receiving 2067 citations. Previous affiliations of Sabine Hellwig include University Medical Center Freiburg.
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Journal ArticleDOI
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
Rik Ossenkoppele,Willemijn J. Jansen,Gil D. Rabinovici,Dirk L. Knol,Wiesje M. van der Flier,Bart N.M. van Berckel,Philip Scheltens,Pieter Jelle Visser,Sander C.J. Verfaillie,Marissa D. Zwan,Sofie Adriaanse,Adriaan A. Lammertsma,Frederik Barkhof,William J. Jagust,Bruce L. Miller,Howard J. Rosen,Susan M. Landau,Victor L. Villemagne,Christopher C. Rowe,Dong Y. Lee,Duk L. Na,Sang W. Seo,Marie Sarazin,Catherine M. Roe,Osama Sabri,Henryk Barthel,Norman Koglin,John R. Hodges,Cristian E. Leyton,Rik Vandenberghe,Koen Van Laere,Alexander Drzezga,Stefan Förster,Timo Grimmer,Pascual Sánchez-Juan,José M. Carril,Vincent Mok,Vincent Camus,William E. Klunk,Ann D. Cohen,Philipp T. Meyer,Sabine Hellwig,Andrew B. Newberg,Kristian Steen Frederiksen,Adam S. Fleisher,Mark A. Mintun,David A. Wolk,Agneta Nordberg,Juha O. Rinne,Gaël Chételat,Alberto Lleó,Rafael Blesa,Juan Fortea,Karine Madsen,Karen M. Rodrigue,David J. Brooks +55 more
TL;DR: Findings indicate the potential clinical utility of amyloid imaging for differential diagnosis in early-onset dementia and to support the clinical diagnosis of participants with AD dementia and noncarrier APOE ε4 status.
Prevalence of Amyloid PET Positivity in Dementia Syndromes
Rik Ossenkoppele,Willemijn J. Jansen,Gil D. Rabinovici,Dirk L. Knol,Wiesje M. van der Flier,Bart N.M. van Berckel,Philip Scheltens,Pieter Jelle Visser,Sander C.J. Verfaillie,Marissa D. Zwan,Sofie Adriaanse,Adriaan A. Lammertsma,Frederik Barkhof,William J. Jagust,Bruce L. Miller,Howard J. Rosen,Susan M. Landau,Victor L. Villemagne,Christopher C. Rowe,Dong Y. Lee,Duk L. Na,Sang W. Seo,Marie Sarazin,Catherine M. Roe,Osama Sabri,Henryk Barthel,Norman Koglin,John R. Hodges,Cristian E. Leyton,Rik Vandenberghe,Koen Van Laere,Alexander Drzezga,Stefan Förster,Timo Grimmer,Pascual Sánchez-Juan,José M. Carril,Vincent Mok,Vincent Camus,William E. Klunk,Ann D. Cohen,Philipp T. Meyer,Sabine Hellwig,Andrew B. Newberg,Kristian Steen Frederiksen,Adam S. Fleisher,Mark A. Mintun,David A. Wolk,Agneta Nordberg,Juha O. Rinne,Gaël Chételat,Alberto Lleó,Rafael Blesa,Juan Fortea,Karine Madsen,Karen M. Rodrigue,David J. Brooks +55 more
Journal ArticleDOI
Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice
Sabine Hellwig,Simone Brioschi,Sandra Dieni,Lars Frings,Annette Masuch,Thomas Blank,Knut Biber +6 more
TL;DR: The data point towards a role of hyper-ramified microglia in the etiology of chronic depression, and the lack of effects in CX3CR1 deficient mice suggests that microgliohyper-ramification is controlled by neuron-microglia signaling via the CX2C axis, however, it remains to be elucidated how hyper-ramsified microGlia contribute to depressive-like behavior.
Journal ArticleDOI
[18F]FDG-PET is superior to [123I]IBZM-SPECT for the differential diagnosis of parkinsonism
Sabine Hellwig,Florian Amtage,Annabelle Kreft,Ralph Buchert,Oliver H. Winz,Werner Vach,Timo S. Spehl,Michel Rijntjes,Bernhard Hellwig,Cornelius Weiller,Christian Winkler,Wolfgang Weber,Oliver Tüscher,Philipp T. Meyer +13 more
TL;DR: The diagnostic accuracy of [18F]FDG-PET for discriminating LBD from APS is considerably higher than for [123I]IBZM-SPECT, and this approach reliably differentiates APS subgroups.
Journal ArticleDOI
Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
Iris Hack,Sabine Hellwig,Dirk Junghans,Bianka Brunne,Hans H. Bock,Shanting Zhao,Michael Frotscher +6 more
TL;DR: Evidence is presented for divergent roles of the two reelin receptors VldLR and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApOER2 being essential for the migration of late generated neocortical neurons.