Sally Mackey

TL;DR: Intensive multifactor risk reduction conducted over 4 years favorably altered the rate of luminal narrowing in coronary arteries of men and women with coronary artery disease and decreased hospitalizations for clinical cardiac events.

TL;DR: The NCEP Step 2 diet failed to lower cholesterol levels in men or women with high-risk lipoprotein levels who did not engage in aerobic exercise, highlighting the importance of physical activity in the treatment of elevated LDL cholesterol levels.

TL;DR: The data suggest that inhibitory receptors may contribute more to NK cell self-tolerance, whereas activating receptors may guide response to pathogens and tumors, and the possibility that discrete NK cell subpopulations could be harnessed for immunotherapeutic strategies in the settings of infection, reproduction, and transplantation.

TL;DR: A variety of alternative dietary strategies can be employed in conjunction with traditional dietary recommendations (i.e., reduce total fat, especially saturated fatty acids and dietary cholesterol) for the management of plasma lipid levels.

TL;DR: It is discovered that closely related B cells often switch to the same class, but lose coherence as somatic mutations accumulate, suggesting that class switch recombination is directed toward specific isotypes by a cell-autonomous imprinted state.