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Amir Horowitz
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 69
Citations - 5481
Amir Horowitz is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 25, co-authored 45 publications receiving 4307 citations. Previous affiliations of Amir Horowitz include New York University & Aaron Diamond AIDS Research Center.
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Journal ArticleDOI
Immunology of COVID-19: Current State of the Science.
Nicolas Vabret,Graham J. Britton,Conor Gruber,Samarth Hegde,Joel Kim,Maria Kuksin,Rachel Levantovsky,Louise Malle,Alvaro Moreira,Matthew D. Park,Luisanna Pia,Emma Risson,Miriam Saffern,Bérengère Salomé,Myvizhi Esai Selvan,Matthew P. Spindler,Jessica Tan,Verena van der Heide,Jill Gregory,Konstantina Alexandropoulos,Nina Bhardwaj,Brian D. Brown,Benjamin Greenbaum,Zeynep H. Gümüş,Dirk Homann,Amir Horowitz,Alice O. Kamphorst,Maria A. Curotto de Lafaille,Saurabh Mehandru,Miriam Merad,Robert M. Samstein,Manasi Agrawal,Mark Aleynick,Meriem Belabed,Matthew Brown,Maria Casanova-Acebes,Jovani Catalan,Monica Centa,Andrew Charap,Andrew K Chan,Steven T. Chen,Jonathan Chung,Cansu Cimen Bozkus,Evan Cody,Francesca Cossarini,Erica Dalla,Nicolas F. Fernandez,John A. Grout,Dan Fu Ruan,Pauline Hamon,Etienne Humblin,Divya Jha,Julia Kodysh,Andrew Leader,Matthew Lin,Katherine E. Lindblad,Daniel Lozano-Ojalvo,Gabrielle Lubitz,Assaf Magen,Zafar Mahmood,Gustavo Martinez-Delgado,Jaime Mateus-Tique,Elliot Meritt,Chang Moon,Justine Noel,Timothy O'Donnell,Miyo Ota,Tamar Plitt,Venu Pothula,Jamie Redes,Ivan Reyes Torres,Mark P. Roberto,Alfonso R. Sanchez-Paulete,Joan Shang,Alessandra Soares Schanoski,Maria Suprun,Michelle Tran,Natalie Vaninov,C. Matthias Wilk,Julio A. Aguirre-Ghiso,Dusan Bogunovic,Judy H. Cho,Jeremiah J. Faith,Emilie K. Grasset,Peter S. Heeger,Ephraim Kenigsberg,Florian Krammer,Uri Laserson +87 more
TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.
Journal ArticleDOI
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract.
Saurabh Mehandru,Michael A. Poles,Michael A. Poles,Klara Tenner-Racz,Amir Horowitz,Amir Horowitz,Arlene Hurley,Christine Hogan,Daniel Boden,Paul Racz,Martin Markowitz +10 more
TL;DR: It is demonstrated that although chronic suppression of HIV-1 permits near-complete immune recovery of the peripheral blood CD4+ T cell population, a significantly greater CD4- T cell loss remains in the GI mucosa, despite up to 5 yr of fully suppressive therapy.
Journal ArticleDOI
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry
Amir Horowitz,Dara M. Strauss-Albee,Michael D. Leipold,Jessica Kubo,Neda Nemat-Gorgani,Ozge C. Dogan,Cornelia L. Dekker,Sally Mackey,Holden T. Maecker,Gary E. Swan,Mark M. Davis,Paul Norman,Lisbeth A. Guethlein,Manisha Desai,Peter Parham,Catherine A. Blish +15 more
TL;DR: The data suggest that inhibitory receptors may contribute more to NK cell self-tolerance, whereas activating receptors may guide response to pathogens and tumors, and the possibility that discrete NK cell subpopulations could be harnessed for immunotherapeutic strategies in the settings of infection, reproduction, and transplantation.
Journal ArticleDOI
Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells
Douglass Wu,Guo-Wen Xing,Michael A. Poles,Amir Horowitz,Yuki Kinjo,Barbara A. Sullivan,Vera Bodmer-Narkevitch,Oliver Plettenburg,Mitchell Kronenberg,Moriya Tsuji,David D. Ho,Chi-Huey Wong +11 more
TL;DR: It is shown that bacterium-derived antigens are also able to stimulate mouse and human NKT cells, and alpha-GalCer is a marine-sponge-derived ligand.
Journal ArticleDOI
Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report.
Martin Markowitz,Hiroshi Mohri,Saurabh Mehandru,Anita Shet,Leslie Berry,Roopa Kalyanaraman,Alexandria Kim,Chris Chung,Patrick Jean-Pierre,Amir Horowitz,Amir Horowitz,Melissa La Mar,Terri Wrin,Neil Parkin,Michael A. Poles,Michael A. Poles,Christos J. Petropoulos,Michael P. Mullen,Daniel Boden,David D. Ho +19 more
TL;DR: The intersection of multidrug resistance and rapid development of AIDS in this patient is of concern, especially in view of his case history, which includes high-risk sexual contacts and use of metamfetamine.