L
Lisbeth A. Guethlein
Researcher at Stanford University
Publications - 106
Citations - 8255
Lisbeth A. Guethlein is an academic researcher from Stanford University. The author has contributed to research in topics: Human leukocyte antigen & Major histocompatibility complex. The author has an hindex of 44, co-authored 97 publications receiving 7417 citations.
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Journal ArticleDOI
Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia
Sarah Cooley,Daniel J. Weisdorf,Lisbeth A. Guethlein,John P. Klein,Tao Wang,Chap T. Le,Steven G.E. Marsh,Daniel E. Geraghty,Stephen R. Spellman,Michael Haagenson,Martha Ladner,Elizabeth Trachtenberg,Peter Parham,Jeffrey S. Miller +13 more
TL;DR: KIR genotyping of several best HLA-matched potential unrelated donors should substantially increase the frequency of transplants by using grafts with favorable KIR gene content, which could result in superior disease-free survival for patients with AML.
Journal ArticleDOI
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry
Amir Horowitz,Dara M. Strauss-Albee,Michael D. Leipold,Jessica Kubo,Neda Nemat-Gorgani,Ozge C. Dogan,Cornelia L. Dekker,Sally Mackey,Holden T. Maecker,Gary E. Swan,Mark M. Davis,Paul Norman,Lisbeth A. Guethlein,Manisha Desai,Peter Parham,Catherine A. Blish +15 more
TL;DR: The data suggest that inhibitory receptors may contribute more to NK cell self-tolerance, whereas activating receptors may guide response to pathogens and tumors, and the possibility that discrete NK cell subpopulations could be harnessed for immunotherapeutic strategies in the settings of infection, reproduction, and transplantation.
Journal ArticleDOI
The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans
Laurent Abi-Rached,Matthew J. Jobin,Matthew J. Jobin,Subhash Kulkarni,A.J. McWhinnie,Klara Dalva,Loren Gragert,Farbod Babrzadeh,Baback Gharizadeh,Ma Luo,Ma Luo,Francis A. Plummer,Francis A. Plummer,Joshua Kimani,Mary Carrington,Mary Carrington,Derek Middleton,Raja Rajalingam,Meral Beksac,Steven G.E. Marsh,Steven G.E. Marsh,Martin Maiers,Lisbeth A. Guethlein,Sofia Tavoularis,Ann Margaret Little,Ann Margaret Little,Richard E. Green,Paul Norman,Peter Parham +28 more
TL;DR: Analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals.
Journal ArticleDOI
Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia
Sarah Cooley,Elizabeth Trachtenberg,Tracy L. Bergemann,Koy Saeteurn,John P. Klein,Chap T. Le,Steven G.E. Marsh,Lisbeth A. Guethlein,Peter Parham,Jeffrey S. Miller,Daniel J. Weisdorf +10 more
TL;DR: KIR genotyping of prospective donors, in addition to HLA typing, should be performed to identify HLA-matched donors with B KIR haplotypes to confer significant survival benefit to patients undergoing T-replete HCT for AML.
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Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
Steven G.E. Marsh,Peter Parham,Bo Dupont,Daniel E. Geraghty,John Trowsdale,Derek Middleton,Carlos Vilches,Mary Carrington,Campbell S. Witt,Lisbeth A. Guethlein,Heather G. Shilling,CA Garcia,Katharine C. Hsu,H Wain +13 more
TL;DR: It was decided to form a subcommittee to coordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors (KIRs) and a request has been made by the International Union of Immunological Societies to provide a standardized nomenclature for the expressed protein products of the KIR genes.