S
Samuel I. Gunderson
Researcher at Rutgers University
Publications - 47
Citations - 3088
Samuel I. Gunderson is an academic researcher from Rutgers University. The author has contributed to research in topics: Polyadenylation & snRNP. The author has an hindex of 30, co-authored 47 publications receiving 2937 citations. Previous affiliations of Samuel I. Gunderson include Radboud University Nijmegen & University of Wisconsin-Madison.
Papers
More filters
Journal ArticleDOI
U1 snRNP Inhibits Pre-mRNA Polyadenylation through a Direct Interaction between U1 70K and Poly(A) Polymerase
TL;DR: Conservation of the U1 70K inhibitory domains suggests that polyadenylation regulation via PAP inhibition may be more widespread than previously thought.
Journal ArticleDOI
PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine.
Jin-Hyung Lee,Jeffry R. Cook,Zhi-Hong Yang,Olga Mirochnitchenko,Samuel I. Gunderson,Arthur M. Felix,Nicole Herth,Ralf Hoffmann,Sidney Pestka +8 more
TL;DR: The cDNA for PRMT7, a recently discovered human protein-arginine methyltransferase (PRMT), was cloned and expressed in Escherichia coli and mammalian cells, demonstrating thatPRMT7 (like PRMT5) is a Type II methyl transferase capable of producing SDMA modifications in proteins.
Journal ArticleDOI
The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase
Samuel I. Gunderson,Katrin Beyer,Georges Martin,Water Keller,Wilbert C. Boelens,Iain W. Mattaj +5 more
TL;DR: The human U1 snRNP-specific U1A protein autoregulates its production by binding its own pre-mRNA and inhibiting polyadenylation, and is shown to specifically interact with mammalian PAP in vitro.
Journal ArticleDOI
Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation.
Wencheng Li,Bei You,Mainul Hoque,Dinghai Zheng,Wenting Luo,Zhe Ji,Ji Yeon Park,Samuel I. Gunderson,Auinash Kalsotra,James L. Manley,Bin Tian +10 more
TL;DR: An APA code where an APA event in a given cellular context is regulated by a number of parameters, including relative location to the TSS, splicing context, distance between competing pAs, surrounding cis elements and concentrations of core C/P factors are supported.
Journal ArticleDOI
The human U1 snRNP-Specific U1A protein inhibits polyadenylation of its own pre-mRNA
Wilbert C. Boelens,Eric Jansen,Walther J. van Venrooij,Renata Stripecke,Iain W. Mattaj,Samuel I. Gunderson +5 more
TL;DR: In vitro and in vivo experiments demonstrate that excess U1A protein specifically inhibits polyadenylation of pre-mRNAs that contain the conserved 3' UTR from human U1a mRNA.