S
Sandra Barth
Researcher at University of Bonn
Publications - 13
Citations - 1523
Sandra Barth is an academic researcher from University of Bonn. The author has contributed to research in topics: IRF6 & Genome-wide association study. The author has an hindex of 11, co-authored 13 publications receiving 1324 citations.
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Journal ArticleDOI
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
Stefanie Birnbaum,Stefanie Birnbaum,Kerstin U. Ludwig,Heiko Reutter,Stefan Herms,Michael Steffens,Michele Rubini,Carlotta Baluardo,Melissa Ferrian,Nilma Almeida de Assis,Margrieta A. Alblas,Sandra Barth,Jan Freudenberg,Carola Lauster,Gül Schmidt,Martin Scheer,Bert Braumann,Stefaan J. Bergé,Rudolf H. Reich,Franziska Schiefke,Alexander Hemprich,Simone Pötzsch,Régine P.M. Steegers-Theunissen,Bernd Pötzsch,Susanne Moebus,Bernhard Horsthemke,Franz-Josef Kramer,Thomas F. Wienker,Peter A. Mossey,Peter Propping,Sven Cichon,Per Hoffmann,Michael Knapp,Markus M. Nöthen,Elisabeth Mangold +34 more
TL;DR: A 640-kb region at chromosome 8q24.21 was found to contain multiple markers with highly significant evidence for association with the cleft phenotype, including three markers that reached genome-wide significance.
Journal ArticleDOI
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
Elisabeth Mangold,Kerstin U. Ludwig,Stefanie Birnbaum,Carlotta Baluardo,Melissa Ferrian,Stefan Herms,Heiko Reutter,Nilma Almeida de Assis,Taofik Al Chawa,Manuel Mattheisen,Michael Steffens,Sandra Barth,Nadine Kluck,Anna Paul,Jessica Becker,Carola Lauster,Gül Schmidt,Bert Braumann,Martin Scheer,Rudolf H. Reich,Alexander Hemprich,Simone Pötzsch,Bettina Blaumeiser,Susanne Moebus,Michael Krawczak,Stefan Schreiber,Thomas Meitinger,Hans Erich Wichmann,Régine P.M. Steegers-Theunissen,Franz Josef Kramer,Sven Cichon,Peter Propping,Thomas F. Wienker,Michael Knapp,Michele Rubini,Peter A. Mossey,Per Hoffmann,Markus M. Nöthen +37 more
TL;DR: A genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/ P triads is conducted.
Journal ArticleDOI
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci
Kerstin U. Ludwig,Elisabeth Mangold,Stefan Herms,Stefanie Nowak,Stefanie Nowak,Heiko Reutter,Heiko Reutter,Anna Paul,Jessica Becker,Ruth Herberz,Taofik AlChawa,Entessar Nasser,Anne C. Böhmer,Manuel Mattheisen,Manuel Mattheisen,Margrieta A. Alblas,Sandra Barth,Nadine Kluck,Carola Lauster,Bert Braumann,Rudolf H. Reich,Alexander Hemprich,Simone Pötzsch,Bettina Blaumeiser,Nikolaos Daratsianos,Thomas Kreusch,Jeffrey C. Murray,Mary L. Marazita,Ingo Ruczinski,Alan F. Scott,Terri H. Beaty,Franz Josef Kramer,Thomas F. Wienker,Régine P.M. Steegers-Theunissen,Michele Rubini,Peter A. Mossey,Per Hoffmann,Christoph Lange,Christoph Lange,Sven Cichon,Peter Propping,Michael Knapp,Markus M. Nöthen +42 more
TL;DR: The first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date identified the first specific genetic risk factor for NSCLP.
Journal ArticleDOI
Follow-Up Study of the First Genome-Wide Association Scan in Alopecia Areata: IL13 and KIAA0350 as Susceptibility Loci Supported with Genome-Wide Significance
Dagny Jagielska,Dagny Jagielska,Silke Redler,Felix F. Brockschmidt,Christine Herold,Sandra M. Pasternack,Natalie Garcia Bartels,Sandra Hanneken,Sibylle Eigelshoven,Melanie Refke,Sandra Barth,Kathrin A. Giehl,Roland Kruse,Gerhard Lutz,Hans Wolff,Bettina Blaumeiser,Markus Böhm,Ulrike Blume-Peytavi,Tim Becker,Tim Becker,Markus M. Nöthen,Regina C. Betz +21 more
TL;DR: In this paper, the authors conducted a follow-up association analysis of the first genome-wide association study (GWAS) of alopecia areata (AA) in a North-American sample, and this identified eight susceptibility loci surpassing genomewide significance.
Journal ArticleDOI
Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip ± Cleft Palate and Cleft Palate Only.
Kerstin U. Ludwig,Anne C. Böhmer,John Bowes,Milos Nikolic,Nina Ishorst,Niki D. Wyatt,Nigel L. Hammond,Lina Gölz,Frederic Thieme,Sandra Barth,Hannah Schuenke,Johanna Klamt,Malte Spielmann,Khalid Aldhorae,Augusto Rojas-Martinez,Markus M. Nöthen,Alvaro Rada-Iglesias,Michael J. Dixon,Michael Knapp,Elisabeth Mangold +19 more
TL;DR: The data suggest that, while common variants are strongly contributing to risk for nsCL/P, they do not seem to be involved in nsCPO which might be more often caused by rare deleterious variants.