S
Sandra Carvalho
Researcher at University of Dundee
Publications - 8
Citations - 203
Sandra Carvalho is an academic researcher from University of Dundee. The author has contributed to research in topics: Leishmania infantum & Midgut. The author has an hindex of 4, co-authored 8 publications receiving 154 citations. Previous affiliations of Sandra Carvalho include Instituto de Biologia Molecular e Celular.
Papers
More filters
Journal ArticleDOI
The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival.
TL;DR: Ex vivo infection assays suggest that wild-type levels of LiTXN1 are required for optimal L. infantum virulence, and confirm the essentiality of Li TXN1 throughout the life cycle of the parasite, namely in the disease-causing amastigote stage.
Journal ArticleDOI
Heme as a source of iron to Leishmania infantum amastigotes.
Sandra Carvalho,Tânia Cruz,Nuno Santarém,Helena Castro,Vítor Costa,Vítor Costa,Ana M. Tomás,Ana M. Tomás +7 more
TL;DR: Evidence is presented that a ligand at the surface of amastigotes binds hemin with high-affinity (Kd=0.044nM) and may function in intracellular transport of heme while hemoglobin internalization occurs through a different molecule.
Journal ArticleDOI
Mitochondrial Redox Metabolism in Trypanosomatids Is Independent of Tryparedoxin Activity
Helena Castro,Susana Romao,Sandra Carvalho,Filipa Teixeira,Carla A Sousa,Ana M. Tomás,Ana M. Tomás +6 more
TL;DR: The separation of trypanosomatid TXN sequences into two classes is proposed and supported by phylogenetic analysis: i) class I, encoding active TXNs, and ii) class II, coding for TA proteins unlikely to function as TXNs.
Journal ArticleDOI
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Charles E. Mowbray,Stéphanie Braillard,Paul Alan Glossop,Gavin A. Whitlock,Robert T. Jacobs,Jason Speake,Bharathi Pandi,Bakela Nare,Louis Maes,Vanessa Yardley,Yvonne Freund,Richard J. Wall,Sandra Carvalho,Davide Bello,Magali Van den Kerkhof,Guy Caljon,Ian H. Gilbert,Victoriano Corpas-López,Iva Lukac,Stephen Patterson,Fabio Zuccotto,Susan Wyllie +21 more
TL;DR: In this article, the authors describe the development and optimization of this series, leading to the identification of compounds with potent in vitro and in vivo antileishmanial activity, including DNDI-6148, a preclinical candidate for the treatment of Visceral leishmaniasis.
Journal ArticleDOI
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani
Richard J. Wall,Sandra Carvalho,Rachel Milne,Juan A. Bueren-Calabuig,Sonia Moniz,Juan Cantizani-Perez,Lorna MacLean,Albane Kessler,Ignacio Cotillo,Lalitha Sastry,Sujatha Manthri,Stephen Patterson,Fabio Zuccotto,Stephen Thompson,Julio Martin,Maria L. Marco,Timothy J. Miles,Manu De Rycker,Michael G. Thomas,Alan H. Fairlamb,Ian H. Gilbert,Susan Wyllie +21 more
TL;DR: Comprehensive genetic and biochemical studies are described to determine the targets of three unrelated phenotypically active compounds, identified as a promiscuous drug target in Leishmania donovani and Trypanosoma cruzi with a propensity to rapidly mutate.