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Filipa Teixeira
Researcher at Instituto de Biologia Molecular e Celular
Publications - 8
Citations - 390
Filipa Teixeira is an academic researcher from Instituto de Biologia Molecular e Celular. The author has contributed to research in topics: Leishmania infantum & Chaperone (protein). The author has an hindex of 7, co-authored 8 publications receiving 325 citations. Previous affiliations of Filipa Teixeira include University of Michigan.
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Journal ArticleDOI
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
Hanseong Kim,Sojin An,Seung Hyun Ro,Filipa Teixeira,Gyeong Jin Park,Gyeong Jin Park,Cheal Kim,Chun-Seok Cho,Jeong Sig Kim,Jeong Sig Kim,Ursula Jakob,Jun Hee Lee,Uhn-Soo Cho +12 more
TL;DR: The crystal structure of human Sestrin2 is reported, and it is shown that hSesn2 is twofold pseudo-symmetric with two globular subdomains, which are structurally similar but functionally distinct from each other.
Journal ArticleDOI
Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum
Filipa Teixeira,Helena Castro,Helena Castro,Tânia Cruz,Tânia Cruz,Eric Tse,Philipp Koldewey,Daniel R. Southworth,Ana M. Tomás,Ana M. Tomás,Ursula Jakob +10 more
TL;DR: It is demonstrated that in the vector-borne protozoan parasite Leishmania infantum, mitochondrial peroxiredoxin (Prx) exerts intrinsic ATP-independent chaperone activity, protecting a wide variety of different proteins against heat stress-mediated unfolding in vitro and in vivo.
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Leishmania Mitochondrial Peroxiredoxin Plays a Crucial Peroxidase-Unrelated Role during Infection: Insight into Its Novel Chaperone Activity
Helena Castro,Filipa Teixeira,Susana Romao,Mariana Santos,Tânia Cruz,Manuela Flórido,Rui Appelberg,Rui Appelberg,Pedro Oliveira,Frederico Ferreira-da-Silva,Ana M. Tomás,Ana M. Tomás +11 more
TL;DR: It is shown, for the first time, that these 2-Cys peroxiredoxins can be determinant for pathogenicity independently of their peroxidase activity, and the findings reported here change the paradigm which regards all trypanosomatid 2-cysteine peroxires as peroxide-eliminating devices.
Journal ArticleDOI
Mitochondrial Redox Metabolism in Trypanosomatids Is Independent of Tryparedoxin Activity
Helena Castro,Susana Romao,Sandra Carvalho,Filipa Teixeira,Carla A Sousa,Ana M. Tomás,Ana M. Tomás +6 more
TL;DR: The separation of trypanosomatid TXN sequences into two classes is proposed and supported by phylogenetic analysis: i) class I, encoding active TXNs, and ii) class II, coding for TA proteins unlikely to function as TXNs.
Journal ArticleDOI
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies.
Raquel Fonseca Rodrigues,Denise Barçante Castro-Pinto,Aurea Echevarria,Camilla Moretto dos Reis,Catarina de Nigris Del Cistia,Carlos Mauricio R. Sant'Anna,Filipa Teixeira,Helena Castro,Marilene M. Canto-Cavalheiro,Leonor L. Leon,Ana M. Tomás +10 more
TL;DR: In this article, a series of mesoionic 1,3,4thiadiazolium-2-aminide derivatives have been studied to determine their effect on trypanothione reductase (TryR) activity in Leishmania sp. and trypanosoma cruzi.