Journal ArticleDOI
The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival.
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TLDR
Ex vivo infection assays suggest that wild-type levels of LiTXN1 are required for optimal L. infantum virulence, and confirm the essentiality of Li TXN1 throughout the life cycle of the parasite, namely in the disease-causing amastigote stage.About:
This article is published in International Journal for Parasitology.The article was published on 2009-05-01. It has received 69 citations till now. The article focuses on the topics: Leishmania infantum & Amastigote.read more
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Journal ArticleDOI
Polyamine metabolism in Leishmania : from arginine to trypanothione
Gianni Colotti,Andrea Ilari +1 more
TL;DR: E enzymes involved in spermidine synthesis and its utilization, i.e. ARG, ODC, AdoMetDC, SpdS and, in particular, TryS and TR, are promising targets for drug development.
Journal ArticleDOI
Low-Molecular-Mass Antioxidants in Parasites
TL;DR: The current organism-wide RNA-interference and proteome analyses are supposed to reveal many more interesting candidates for future drug development approaches directed against the parasite antioxidant defense systems.
Journal ArticleDOI
Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids.
Bruno Manta,Marcelo A. Comini,Andrea Medeiros,Andrea Medeiros,Martín Hugo,Madia Trujillo,Rafael Radi +6 more
TL;DR: The minimalist thiol-redox system, developed by trypanosomatids, is an example of metabolic fitness driven by the remarkable physicochemical properties of a glutathione derivative, and a feature unique to the order Kinetoplastida.
Journal ArticleDOI
Peroxiredoxins in Parasites
TL;DR: A systematic Prx naming convention is introduced that is consistent between organisms and informative about structural and evolutionary relationships and should stimulate the crossfertilization of ideas among parasitologists and with the broader redox research community.
Journal ArticleDOI
Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation
TL;DR: Comparison of morphology, infectivity and protein expression of L. donovani LD1S grown in host free (axenic) culture, or exclusively propagated in infected hamsters, is compared to reveal parasite traits absent in axenic but selected for in hamster‐derived amastigotes through leishmanicidal host activities.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
Physiological functions of thioredoxin and thioredoxin reductase.
Elias S.J. Arnér,Arne Holmgren +1 more
TL;DR: All mammalian thioredoxin reduct enzyme isozymes are homologous to glutathione reductase and contain a conserved C-terminal elongation with a cysteine-selenocysteine sequence forming a redox-active selenenylsulfide/selenolthiol active site and are inhibited by goldthioglucose and other clinically used drugs.
Journal ArticleDOI
Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?
François Chappuis,François Chappuis,Shyam Sundar,Asrat Hailu,H. W. Ghalib,Suman Rijal,Rosanna W. Peeling,Jorge Alvar,Marleen Boelaert +8 more
TL;DR: Millefosine, paromomycin and liposomal amphotericin B are gradually replacing pentavalent antimonials and conventional amphoteric in B as the preferred treatments in some regions, but in other areas these drugs are still being evaluated in both mono- and combination therapies.
Journal ArticleDOI
Metabolism and functions of trypanothione in the kinetoplastida
Alan H. Fairlamb,Anthony Cerami +1 more
TL;DR: The purification and properties of three key enzymes (glutathionylspermidine synthetases, trypanothione synthetase, and trypanothsione reductase) are discussed, and the catalytic mechanism, substrate-specificity, andThe three-dimensional structure of trypanOTHione reduCTase are compared to that of glutathione reductor.
Journal ArticleDOI
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids
TL;DR: The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-sperMidine conjugate, N1,N8-bis(L-gamma-glutamyl-L-hemicystinyl-glycyl)spermidine, for which the trivial name trypanothione is proposed.
Related Papers (5)
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
Role of peroxidoxins in Leishmania chagasi survival. Evidence of an enzymatic defense against nitrosative stress.
Stephen D. Barr,Lashitew Gedamu +1 more