Sandra K. Burchett

TL;DR: Neither higher HIV-1 RNA levels early in pregnancy nor higher levels late in pregnancy were associated with the timing of infection in the infants, and in pregnant women with HIV- 1 infection the level of plasma HIV-2 RNA predicts the risk but not the time of transmission of HIV-3 to their infants.

TL;DR: Investigation of mother–child transmission in the setting of HLA-B27 expression suggests that CTL escape mutations in epitopes associated with suppression of viraemia will accumulate as the epidemic progresses, and therefore have important implications for vaccine design.

TL;DR: Pregnant women in early labor who were without symptoms or signs of genital HSV infection were prospectively obtained HSV cultures from the cervix and external genitalia to define the risk factors associated with neonatal acquisition of herpes simplex virus (HSV) infection.

TL;DR: With HSV infection limited to the skin, eyes, or mouth, the presence of three or more recurrences of vesicles was associated with an increased risk of neurologic impairment as compared with two or fewer recurrence.

TL;DR: In this article, a controlled trial comparing vidarabine with acyclovir for the treatment of neonatal HSV infection was conducted, where infants less than one month of age with virologically confirmed infection were randomly and blindly assigned to receive either intravenous vidaramabine (30 mg per kilogram of body weight per day; n = 95) or acalovir (30mg per kg per day, n = 107) for 10 days.