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Robert Funkhouser
Researcher at Los Alamos National Laboratory
Publications - 6
Citations - 1463
Robert Funkhouser is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Human leukocyte antigen & Epitope. The author has an hindex of 5, co-authored 6 publications receiving 1422 citations. Previous affiliations of Robert Funkhouser include Santa Fe Institute.
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Journal ArticleDOI
Evolution and transmission of stable CTL escape mutations in HIV infection
Philip J. R. Goulder,Christian Brander,Yanhua Tang,Cécile Tremblay,Robert A. Colbert,Marylyn M. Addo,Eric S. Rosenberg,Thi Nguyen,Rachel L. Allen,Alicja Trocha,Marcus Altfeld,Suqin He,Michael Bunce,Robert Funkhouser,Stephen I. Pelton,Sandra K. Burchett,Kenneth McIntosh,Bette T. Korber,Bruce D. Walker +18 more
TL;DR: Investigation of mother–child transmission in the setting of HLA-B27 expression suggests that CTL escape mutations in epitopes associated with suppression of viraemia will accumulate as the epidemic progresses, and therefore have important implications for vaccine design.
Journal ArticleDOI
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.
Will Fischer,Simon Perkins,James Theiler,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Karina Yusim,Robert Funkhouser,Carla Kuiken,Barton F. Haynes,Norman L. Letvin,Bruce D. Walker,Beatrice H. Hahn,Bette T. Korber,Bette T. Korber +13 more
TL;DR: It was found that coverage of viral diversity using mosaics was greatly increased compared to coverage by natural-sequence vaccine candidates, for both variable and conserved proteins; for conserved HIV-1 proteins, global coverage may be feasible.
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Advantage of rare HLA supertype in HIV disease progression.
Elizabeth Trachtenberg,Bette T. Korber,Bette T. Korber,Cristina Sollars,Thomas B. Kepler,Thomas B. Kepler,Peter T. Hraber,Elizabeth Hayes,Robert Funkhouser,Robert Funkhouser,Michael L. Fugate,James Theiler,Yen S. Hsu,Kevin J. Kunstman,Samuel Wu,John P. Phair,Henry A. Erlich,Henry A. Erlich,Steven M. Wolinsky +18 more
TL;DR: The correlation of the frequency of the HLA supertypes with viral load suggests that HIV adapts to the most frequent alleles in the population, providing a selective advantage for those individuals who express rare alleles.
Journal ArticleDOI
Los alamos hepatitis C immunology database.
Karina Yusim,Russell Richardson,Ning Tao,Anita Dalwani,Ashish Agrawal,James J. Szinger,Robert Funkhouser,Bette T. Korber,Carla Kuiken +8 more
TL;DR: The types of data and services that the new database offers, the tools provided and the database framework are described in detail.
Journal ArticleDOI
Increased Sequence Diversity Coverage Improves Detection of HIV-Specific T Cell Responses
Nicole Frahm,Daniel Kaufmann,Karina Yusim,Mark Muldoon,Can Keşmir,Can Keşmir,Caitlyn Linde,Will Fischer,Todd M. Allen,Bin Li,Ben H. McMahon,Kellie Faircloth,Hannah S. Hewitt,Elizabeth W Mackey,Toshiyuki Miura,Ashok Khatri,Steven M. Wolinsky,Andrew J. McMichael,Robert Funkhouser,Bruce D. Walker,Bruce D. Walker,Christian Brander,Bette T. Korber,Bette T. Korber +23 more
TL;DR: The design of a peptide test set with significantly increased coverage of HIV sequence diversity by including alternative amino acids at variable positions during the peptide synthesis step is reported, which afford a cost-effective and significantly more complete view of the host immune response to HIV.