Sara Piccinin

TL;DR: It is shown that senescence, triggered by the expression of an activated oncogene (H-RasV12) in normal human cells, is a consequence of the activation of a robust DDR, and proposed that OIS results from the enforcement of a DDR triggered by oncogen-induced DNA hyper-replication.

TL;DR: It is shown that a large fraction of human cancers overexpress Twist1 and/or Twist2, suggesting an unanticipated direct link between early escape from failsafe programs and the acquisition of invasive features by cancer cells.

TL;DR: The hypothesis that ordinary lipomas may form a molecular genetic and morphological continuum with ALT is supported and the immunohistochemical analysis of mdm2 and cdk4 may help to increase diagnostic accuracy is indicated.

TL;DR: The expression of CDC25A, CDC25B, and CDC25C genes in 20 squamous cell carcinomas of the head and neck are analyzed by quantitative reverse transcription-PCR on the basis of the evidence that CDC25 phosphatases can act as oncogenes.

TL;DR: It is reported that the combined expression of adenovirus E1A, Ha-RasV12, and MDM2 is sufficient to convert a normal human cell into a cancer cell and provides evidence that activation of telomere maintenance strategies is not an obligate characteristic of tumorigenic human cells.