S
Sarah Smith
Researcher at Medical Research Council
Publications - 14
Citations - 2930
Sarah Smith is an academic researcher from Medical Research Council. The author has contributed to research in topics: Genome & Fugu. The author has an hindex of 11, co-authored 14 publications receiving 2829 citations. Previous affiliations of Sarah Smith include Agency for Science, Technology and Research & Queen Mary University of London.
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Journal ArticleDOI
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
Samuel Aparicio,Jarrod Chapman,Elia Stupka,Nik Putnam,Jer Ming Chia,Paramvir S. Dehal,Alan Christoffels,Sam Rash,Shawn Hoon,Arian F.A. Smit,Maarten D. Sollewijn Gelpke,Jared C. Roach,Tania Oh,Isaac Ho,Marie Wong,Chris Detter,Frans Verhoef,Paul Predki,Alice Tay,Susan Lucas,Paul G. Richardson,Sarah Smith,Melody S. Clark,Yvonne J. K. Edwards,Norman A. Doggett,Andrey Zharkikh,Sean V. Tavtigian,Dmitry Pruss,Mary Barnstead,Cheryl Evans,Holly Baden,Justin Powell,Gustavo Glusman,Lee Rowen,Leroy Hood,Y. H. Tan,Greg Elgar,Trevor Hawkins,Byrappa Venkatesh,Daniel S. Rokhsar,Sydney Brenner +40 more
TL;DR: The Fugu rubripes genome has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds as discussed by the authors.
Journal ArticleDOI
Highly conserved non-coding sequences are associated with vertebrate development.
Adam Woolfe,Martin Goodson,Debbie K. Goode,Phil Snell,Gayle K. McEwen,Tanya Vavouri,Sarah Smith,Phil North,Heather Callaway,Krys Kelly,Klaudia Walter,Irina I. Abnizova,Walter R. Gilks,Yvonne J. K. Edwards,Julie E. Cooke,Greg Elgar +15 more
TL;DR: A whole-genome comparison between humans and the pufferfish, Fugu rubripes, is used to identify nearly 1,400 highly conserved non-coding sequences, which are likely to form part of the genomic circuitry that uniquely defines vertebrate development.
Journal ArticleDOI
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
Toshana L. Foster,Harry Wilson,Shilpa S. Iyer,Karen P. Coss,Katherine Doores,Sarah Smith,Paul Kellam,Andrés Finzi,Persephone Borrow,Beatrice H. Hahn,Stuart J. D. Neil +10 more
TL;DR: It is found that transmitted founder HIV-1, which establishes de novo infections, is uniquely resistant to the antiviral activity of IFITMs, and that escape from adaptive immune responses exposes the virus to antiviral restriction.
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Generation and Analysis of 25 Mb of Genomic DNA from the Pufferfish Fugu rubripes by Sequence Scanning
Greg Elgar,Melody S. Clark,Stephen Meek,Sarah Smith,Sarah Warner,Yvonne J. K. Edwards,Nassima Bouchireb,Amanda Cottage,Giles S.H. Yeo,Yagnesh Umrania,Gary Williams,Sydney Brenner +11 more
TL;DR: This project highlights the utility of using the Fugu genome in comparative DNA sequence analyses, and makes some estimation of the syntenic relationship between mammals and Fugu and looked at the efficacy of ORF prediction from short, unedited Fugu genomic sequences.
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CONDOR: a database resource of developmentally associated conserved non-coding elements
Adam Woolfe,Adam Woolfe,Debbie K. Goode,Julie E. Cooke,Heather Callaway,Sarah Smith,Phil Snell,Gayle K. McEwen,Gayle K. McEwen,Greg Elgar +9 more
TL;DR: By providing access to data with an approachable graphics interface, the CONDOR database presents a rich resource for further studies into the regulation and evolution of genes involved in early development.