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Sarah X.L. Huang
Researcher at Columbia University Medical Center
Publications - 11
Citations - 1765
Sarah X.L. Huang is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Lung. The author has an hindex of 9, co-authored 9 publications receiving 1280 citations. Previous affiliations of Sarah X.L. Huang include University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
Sarah X.L. Huang,Mohammad Naimul Islam,John D. O’Neill,Zheng Hu,Yong-Guang Yang,Ya-Wen Chen,Melanie Mumau,Michael D. Green,Gordana Vunjak-Novakovic,Jahar Bhattacharya,Hans-Willem Snoeck +10 more
TL;DR: Long-term differentiation of hPSCs in vivo and in vitro yielded basal, goblet, Clara, ciliated, type I and type II alveolar epithelial cells, which may be useful for deriving patient-specific therapeutic cells.
Journal ArticleDOI
A three-dimensional model of human lung development and disease from pluripotent stem cells
Ya-Wen Chen,Sarah X.L. Huang,Ana Luisa Rodrigues Toste de Carvalho,Siu-Hong Ho,Mohammad Naimul Islam,Stefano Volpi,Stefano Volpi,Luigi D. Notarangelo,Michael J. Ciancanelli,Jean-Laurent Casanova,Jahar Bhattacharya,Alice F. Liang,Laura M. Palermo,Matteo Porotto,Anne Moscona,Hans-Willem Snoeck +15 more
TL;DR: Generation from hPSCs of lung bud organoids that contain mesoderm and pulmonary endoderm develop into branching airway and early alveolar structures after xenotransplantation and in Matrigel 3D culture and may provide a useful tool to model lung disease.
Journal ArticleDOI
Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
Michael J. Ciancanelli,Sarah X.L. Huang,Priya Luthra,Hannah Garner,Yuval Itan,Stefano Volpi,Stefano Volpi,Fabien G. Lafaille,Céline Trouillet,Mirco Schmolke,Randy A. Albrecht,Elisabeth Israelsson,Hye Kyung Lim,Melina Casadio,Tamar Hermesh,Lazaro Lorenzo,Lazaro Lorenzo,Lawrence W. Leung,Vincent Pedergnana,Vincent Pedergnana,Bertrand Boisson,Satoshi Okada,Satoshi Okada,Capucine Picard,Benedicte Ringuier,Françoise Troussier,Damien Chaussabel,Damien Chaussabel,Laurent Abel,Laurent Abel,Laurent Abel,Isabelle Pellier,Luigi D. Notarangelo,Adolfo García-Sastre,Christopher F. Basler,Frederic Geissmann,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang,Hans-Willem Snoeck,Jean-Laurent Casanova +40 more
TL;DR: It is suggested that IRF7-dependent amplification of type I and III IFNs is required for protection against primary infection by influenza virus in humans and that severe influenza may result from single-gene inborn errors of immunity.
Journal ArticleDOI
The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells
Sarah X.L. Huang,Michael D. Green,Ana Luisa Rodrigues Toste de Carvalho,Melanie Mumau,Ya-Wen Chen,Sunita L. D’Souza,Hans-Willem Snoeck +6 more
TL;DR: A strategy for directed differentiation of hPSCs into developmental lung progenitors, and their subsequent differentiation into predominantly distal lung epithelial cells.
Journal ArticleDOI
Severe influenza pneumonitis in children with inherited TLR3 deficiency
Hye Kyung Lim,Hye Kyung Lim,Hye Kyung Lim,Sarah X.L. Huang,Sarah X.L. Huang,Jie Chen,Jie Chen,Gaspard Kerner,Gaspard Kerner,Olivier Gilliaux,Paul Bastard,Paul Bastard,Kerry Dobbs,Nicholas Hernandez,Nicolas Goudin,Mary Hasek,Eduardo J. Garcia Reino,Fabien G. Lafaille,Lazaro Lorenzo,Lazaro Lorenzo,Priya Luthra,Tatiana Kochetkov,Benedetta Bigio,Soraya Boucherit,Soraya Boucherit,Flore Rozenberg,Catherine Vedrinne,Michael D. Keller,Yuval Itan,Yuval Itan,Adolfo García-Sastre,Marie Celard,Jordan S. Orange,Michael J. Ciancanelli,Isabelle Meyts,Isabelle Meyts,Qian Zhang,Laurent Abel,Laurent Abel,Laurent Abel,Luigi D. Notarangelo,Hans-Willem Snoeck,Jean-Laurent Casanova,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang +45 more
TL;DR: The authors report three unrelated children with inheritedTLR3 deficiency, impaired TLR3-dependent, IFN-α/β– and/or -λ–mediated, pulmonary epithelial cell–intrinsic immunity to influenza A virus, and life-threatening influenza pneumonitis.