S
Sascha Feuerhahn
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 10
Citations - 995
Sascha Feuerhahn is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Telomere & Telomeric repeat-containing RNAs. The author has an hindex of 9, co-authored 10 publications receiving 891 citations. Previous affiliations of Sascha Feuerhahn include University of Konstanz & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways
TL;DR: It is found that TERRA is regulated during the cell cycle, being lowest in late S phase and peaking in early G1, and the bulk of 3′-terminal UUAGGG repeats have an average length of 200 bases, indicating that the length heterogeneity of TERRA likely stems from its subtelomeric regions.
Journal ArticleDOI
Functional characterization of the TERRA transcriptome at damaged telomeres
Antonio Porro,Sascha Feuerhahn,Julien Delafontaine,Harold Riethman,Jacques Rougemont,Joachim Lingner +5 more
TL;DR: The data elucidate the TERRA landscape and defines critical roles for this RNA in the telomeric DNA damage response and shows that TERRA associates with SUV39H1 H3K9 histone methyltransferase, which promotes accumulation of H3k9me3 at damaged telomeres and end-to-end fusions.
Journal ArticleDOI
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors
Nicolas Charlet-Berguerand,Sascha Feuerhahn,Stephanie E. Kong,Howard Ziserman,Joan W. Conaway,Ronald C. Conaway,Jean-Marc Egly +6 more
TL;DR: It is found that in a purified, reconstituted transcription system, oxidative lesions block elongation by RNA pol II to different extents, depending on the type of lesion, suggesting the presence of a bypass activity.
Journal ArticleDOI
TERRA biogenesis, turnover and implications for function
TL;DR: The current knowledge of TERRA structure, biogenesis and turnover are reviewed and presumed roles of this RNA during replication of telomeric DNA, heterochromatin formation and the regulation of telomere transcription are discussed.
Journal ArticleDOI
TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres
TL;DR: It is shown that following TRF2 depletion, the levels of the long noncoding RNA TERRA increase and LSD1, which binds TERRA, is recruited to telomeres, and that recruitment of LSD1 to deprotected telomereres requires MRE11 and is promoted by TERRA.