Sascha Seidel

TL;DR: It is suggested that blocking ephrin-B2 reverse signalling may be an attractive alternative or combinatorial anti-angiogenic therapy strategy to disrupt VEGFR2 function in tumour angiogenesis.

TL;DR: It is proposed that tumour stem cells are maintained within a hypoxic niche, providing a functional link between the well-established role of hypoxia in stem cell and tumour biology.

TL;DR: An integrated pipeline for automated quantification of cancer metastases and therapeutic antibody targeting, named DeepMACT, which enhanced the fluorescent signal of cancer cells more than 100-fold by applying the vDISCO method and can considerably improve the discovery of effective antibody-based therapeutics at the pre-clinical stage.

TL;DR: Wnt modulates glioma vascularization by regulating PDGF-B expression and prevents programmed cell death in gliomas by reprograming the “wnt-like” signaling pathway.

TL;DR: The findings reveal that PHD3 inactivation provides an alternative route of EGFR activation through which tumour cells sustain proliferative signalling even under conditions of limited oxygen availability.