S
Scot A. Marsters
Researcher at Genentech
Publications - 72
Citations - 17369
Scot A. Marsters is an academic researcher from Genentech. The author has contributed to research in topics: Receptor & Apoptosis. The author has an hindex of 43, co-authored 68 publications receiving 16712 citations.
Papers
More filters
Posted ContentDOI
Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma
Jonathan M. Harnoss,Adrien Le Thomas,Scot A. Marsters,David A. Lawrence,Min Lu,Yung-Chia Ariel Chen,Jing Qing,Klara Totpal,David Kan,Ehud Segal,Heidi J.A. Wallweber,Weiru Wang,Kevin R Clark,Susan Kaufman,Maureen Beresini,Wendy Sandoval,Maria N. Lorenzo,Jiansheng Wu,Justin Ly,Tom De Bruyn,Amy Heidersbachh,Benjamin Haley,Alvin Gogineni,Robby M. Weimer,Dong Lee,Marie-Gabrielle Braun,Joachim Rudolph,Michael J VanWyngarden,Daniel W. Sherbenou,Patricia Gomez-Bougie,Martine Amiot,Diego Acosta-Alvear,Peter Walter,Avi Ashkenazi +33 more
TL;DR: Using genetic and pharmacologic disruption in vitro and in vivo, it is demonstrated that the IRE1α-XBP1s pathway plays a critical role in MM growth and is established as an effective and safe potential small-molecule target for MM therapy.
Patent
PRO20044 nucleic acids
Kevin P. Baker,Napoleone Ferrara,Hans-Peter Gerber,Mary E. Gerritsen,Audrey Goddard,Paul J. Godowski,Austin L. Gurney,Kenneth J. Hillan,Scot A. Marsters,James Pan,Jean-Philippe Stephan,Colin K. Watanabe,P. Mickey Williams,William I. Wood,Weilan Ye +14 more
Journal ArticleDOI
Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma
Riccardo Guidi,Daqi Xu,David F. Choy,Thirumalai R. Ramalingam,Wyne P. Lee,Zora Modrusan,Yuxin Liang,Scot A. Marsters,Avi Ashkenazi,Alison Huynh,Jessica T Mills,Sean Flanagan,Shannon Hambro,Victor Nunez,Laurie Leong,Ashley Cook,Tiffany Hao Tran,Cary D. Austin,Yi Cao,C. C. Clarke,Reynold A. Panettieri,Cynthia J. Koziol-White,William F. Jester,Fen Wang,Mark R. Wilson +24 more
TL;DR: FGFs are established as therapeutic targets for severe asthma patients who do not benefit from ICS after a model of steroid-induced neutrophilic inflammation mediated, in part, by induction of an FGF-dependent epithelial-mesenchymal axis was developed.
Patent
Apo-3 ligand polypeptide
TL;DR: A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided in this paper, where nucleic acid molecules encoding Apo 3 ligand, chimeric molecules and antibodies to Apo3 ligand are also provided.
Journal ArticleDOI
Membrane display and functional analysis of juxtacrine ligand-receptor signaling.
Pradeep M. Nair,Hai Ngu,Eric Torres,Scot A. Marsters,David A. Lawrence,Jean-Philippe Stephan,László G. Kömüves,Avi Ashkenazi +7 more
TL;DR: A small interfering RNA (siRNA) library is screened and specific receptor tyrosine kinases (RTKs) that directly or indirectly modulate apoptosis signaling by a model death ligand through its cognate death receptors are identified.