S
Scott J. Bultman
Researcher at University of North Carolina at Chapel Hill
Publications - 69
Citations - 17000
Scott J. Bultman is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: SWI/SNF & Butyrate. The author has an hindex of 33, co-authored 69 publications receiving 14203 citations. Previous affiliations of Scott J. Bultman include Case Western Reserve University.
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Journal ArticleDOI
Reversible epigenetic modifications of the two cardiac Myosin Heavy Chain genes during changes in expression
TL;DR: Investigation of histone modification patterns that occur over the two cardiac MHC promoters during T3-mediated reversible switching of gene expression indicates that during reciprocal and inducible gene expression H3ac parallels bM HC isoform expression while H3K4me3 parallels expression of the tightly linked aMHC isoform.
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BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility
Monte S. Willis,Darcy Holley,Zhongjing Wang,Xin Chen,Megan T. Quintana,Brian C. Jensen,Manasi Tannu,Joel S. Parker,Darwin Jeyaraj,Mukesh K. Jain,Mukesh K. Jain,Julie A. Wolfram,Hyoung Gon Lee,Scott J. Bultman +13 more
TL;DR: BRG1/BRM and c-MYC have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene in cancer.
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Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base.
TL;DR: 3D organoid culture systems that recapitulate the crypt with respect to stem cell renewal and their ability to give rise to descendants that represent each differentiated cell type are created.
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The CRCbiome study : a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
Ane Sørlie Kværner,Einar Elvbakken Birkeland,Cecilie Bucher-Johannessen,Elina Vinberg,Jan Inge Nordby,Harri Kangas,Vahid Bemanian,Pekka Ellonen,Edoardo Botteri,Erik Natvig,Torbjørn Rognes,Torbjørn Rognes,Eivind Hovig,Eivind Hovig,Robert Lyle,Robert Lyle,Ole Herman Ambur,Ole Herman Ambur,Willem M. de Vos,Willem M. de Vos,Scott J. Bultman,Anette Hjartåker,Rikard Landberg,Mingyang Song,Hege Salvesen Blix,Hege Salvesen Blix,Giske Ursin,Kristin Ranheim Randel,Thomas de Lange,Thomas de Lange,Geir Hoff,Øyvind Holme,Paula Berstad,Trine B. Rounge +33 more
TL;DR: CRCbiome as mentioned in this paper is a prospective biomarker study nested within a large randomized colorectal cancer screening trial in Norway, where participants were randomized to FIT screening with a positive test result.
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New insights into immunomodulation via overexpressing lipoic acid synthase as a therapeutic potential to reduce atherosclerosis
Shaomin Tian,Jun Nakamura,Sylvia Hiller,Stephen W. Simington,Darcy Holley,Roberto Mota,Monte S. Willis,Scott J. Bultman,J. Christopher Luft,Joseph M. DeSimone,Zhenquan Jia,Nobuyo Maeda,Xianwen Yi +12 more
TL;DR: A double mutant mouse model is created, using apolipoprotein E-deficient mice crossbred with mice overexpressing lipoic acid synthase gene (LiasH/H), which sheds light on a new therapeutic strategy using antioxidants to lessen atherosclerosis.