Scott J. Bultman

TL;DR: A hierarchical order of GATA-1-triggered events at a complex locus is defined and a novel mechanism of long-range gene regulation is established to establish a novel way of hematopoiesis and transcriptional activation is established.

TL;DR: It is demonstrated that the BRG1 catalytic subunit of mammalian SWI/SNF-related complexes co-localizes with origin recognition complexes, GINS complexes, and proliferating cell nuclear antigen at sites of DNA replication on extended chromatin fibers, suggesting it does not participate in origin selection but is involved in the firing of origins and the process of replication elongation.

TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis

TL;DR: It is demonstrated for the first time that Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.

TL;DR: The results suggest that SWI/SNF tumor-suppressor activity involves a role in the DNA-damage response (DDR) to attenuate replicative stress and genomic instability.