S
Scott J. Diede
Researcher at Merck & Co.
Publications - 67
Citations - 4447
Scott J. Diede is an academic researcher from Merck & Co.. The author has contributed to research in topics: Pembrolizumab & Medicine. The author has an hindex of 23, co-authored 59 publications receiving 3206 citations. Previous affiliations of Scott J. Diede include University of Washington & University of Chicago.
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Journal ArticleDOI
Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy
Antoni Ribas,Reinhard Dummer,Igor Puzanov,Ari M. Vanderwalde,Robert H.I. Andtbacka,Olivier Michielin,Anthony J. Olszanski,Josep Malvehy,Jonathan Cebon,Eugenio Fernandez,John M. Kirkwood,Thomas F. Gajewski,Lisa Chen,Kevin S. Gorski,Abraham Anderson,Scott J. Diede,Michael E. Lassman,Jennifer Gansert,F. Stephen Hodi,Georgina V. Long +19 more
TL;DR: The findings suggest that oncolytic virotherapy may improve the efficacy of anti-PD-1 therapy by changing the tumor microenvironment.
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Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study
Georgina V. Long,Reinhard Dummer,Omid Hamid,Thomas F. Gajewski,Christian Caglevic,Stéphane Dalle,Ana Arance,Matteo S. Carlino,Jean-Jacques Grob,Tae Min Kim,Lev V. Demidov,Caroline Robert,James Larkin,James R. Anderson,Janet Maleski,Mark M. Jones,Scott J. Diede,Tara C. Mitchell +17 more
TL;DR: Epacadostat 100 mg twice daily plus pembrolizumab did not improve progression-free survival or overall survival compared with placebo plus pEmbrolizumsab in patients with unresectable or metastatic melanoma.
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Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ
TL;DR: An assay in S. cerevisiae that creates a chromosome end immediately adjacent to a short telomeric DNA tract indicates that telomersic DNA synthesis by telomerase is tightly coregulated with the production of the opposite strand.
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Durable Complete Response After Discontinuation of Pembrolizumab in Patients With Metastatic Melanoma
Caroline Robert,Caroline Robert,Antoni Ribas,Omid Hamid,Adil Daud,Jedd D. Wolchok,Anthony M. Joshua,Wen-Jen Hwu,Jeffrey S. Weber,Tara C. Gangadhar,Richard W. Joseph,Roxana S. Dronca,Amita Patnaik,Hassane M. Zarour,Richard F. Kefford,Richard F. Kefford,Peter Hersey,Jin Zhang,James R. Anderson,Scott J. Diede,Scot Ebbinghaus,F. Stephen Hodi +21 more
TL;DR: Patients with metastatic melanoma can have durable complete remission after discontinuation of pembrolizumab, and the low incidence of relapse after median follow-up of approximately 2 years from discontinuation provides hope for a cure for some patients.
Journal ArticleDOI
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.
Suzanne E. Peterson,Anne E. Stellwagen,Scott J. Diede,Scott J. Diede,Miriam S. Singer,Zara W. Haimberger,Catherine O. Johnson,Monika Tzoneva,Daniel E. Gottschling,Daniel E. Gottschling +9 more
TL;DR: It is shown that a 48-nt stem-loop structure within the 1.3-kb TLC1 RNA is necessary and sufficient for disrupting telomeric silencing and shortening telomeres and this short RNA sequence appears to function through an interaction with the conserved DNA end-binding protein Ku.