S
Scott van Hoof
Researcher at German Center for Neurodegenerative Diseases
Publications - 5
Citations - 337
Scott van Hoof is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Epitope & Neutralizing antibody. The author has an hindex of 3, co-authored 4 publications receiving 180 citations. Previous affiliations of Scott van Hoof include Humboldt University of Berlin & Harvard University.
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Journal ArticleDOI
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.
Jakob Kreye,S. Momsen Reincke,Hans Christian Kornau,Hans Christian Kornau,Elisa Sanchez-Sendin,Elisa Sanchez-Sendin,Elisa Sanchez-Sendin,Victor M. Corman,Hejun Liu,Meng Yuan,Nicholas C. Wu,Xueyong Zhu,Chang-Chun D Lee,Jakob Trimpert,Markus Höltje,Kristina Dietert,Laura Stöffler,Laura Stöffler,Niels von Wardenburg,Niels von Wardenburg,Scott van Hoof,Scott van Hoof,Scott van Hoof,Marie A Homeyer,Marie A Homeyer,Julius Hoffmann,Julius Hoffmann,Azza Abdelgawad,Achim D. Gruber,Luca D. Bertzbach,Daria Vladimirova,Lucie Y Li,Lucie Y Li,Paula Charlotte Barthel,Karl Skriner,Andreas C. Hocke,Stefan Hippenstiel,Martin Witzenrath,Norbert Suttorp,Florian Kurth,Florian Kurth,Christiana Franke,Matthias Endres,Dietmar Schmitz,Dietmar Schmitz,Lara Maria Jeworowski,Anja Richter,Marie Luisa Schmidt,Tatjana Schwarz,Marcel A. Müller,Christian Drosten,Daniel Wendisch,Leif E. Sander,Nikolaus Osterrieder,Nikolaus Osterrieder,Ian A. Wilson,Harald Prüss,Harald Prüss,Harald Prüss +58 more
TL;DR: Results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy and should be guided by immunization strategies.
Posted ContentDOI
A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model
Jakob Kreye,S. Momsen Reincke,Hans-Christian Kornau,Hans-Christian Kornau,Elisa Sanchez-Sendin,Elisa Sanchez-Sendin,Elisa Sanchez-Sendin,Victor M. Corman,Hejun Liu,Meng Yuan,Nicholas C. Wu,Xueyong Zhu,Chang-Chun D Lee,Jakob Trimpert,Markus Höltje,Kristina Dietert,Laura Stöffler,Laura Stöffler,Niels von Wardenburg,Niels von Wardenburg,Scott van Hoof,Scott van Hoof,Scott van Hoof,Marie A Homeyer,Marie A Homeyer,Julius Hoffmann,Julius Hoffmann,Azza Abdelgawad,Achim D. Gruber,Luca D. Bertzbach,Daria Vladimirova,Lucie Y Li,Lucie Y Li,Paula Charlotte Barthel,Karl Skriner,Andreas C. Hocke,Stefan Hippenstiel,Martin Witzenrath,Norbert Suttorp,Florian Kurth,Florian Kurth,Christiana Franke,Matthias Endres,Dietmar Schmitz,Dietmar Schmitz,Lara Maria Jeworowski,Anja Richter,Marie Luisa Schmidt,Tatjana Schwarz,Marcel A. Müller,Christian Drosten,Daniel Wendisch,Leif E. Sander,Nikolaus Osterrieder,Ian A. Wilson,Harald Prüss,Harald Prüss,Harald Prüss +57 more
TL;DR: Results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy and should be guided by immunization strategies.
Journal ArticleDOI
Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures.
Jakob Kreye,Sukhvir Wright,Sukhvir Wright,Adriana van Casteren,Laura Stöffler,Laura Stöffler,Marie-Luise Machule,Marie-Luise Machule,S. Momsen Reincke,Marc Nikolaus,Marc Nikolaus,Scott van Hoof,Scott van Hoof,Scott van Hoof,Elisa Sanchez-Sendin,Elisa Sanchez-Sendin,Elisa Sanchez-Sendin,Marie A Homeyer,Marie A Homeyer,César Cordero Gómez,César Cordero Gómez,Hans-Christian Kornau,Hans-Christian Kornau,Dietmar Schmitz,Dietmar Schmitz,Angela M. Kaindl,Philipp Boehm-Sturm,Susanne Mueller,Max A Wilson,Manoj A. Upadhya,Divya R Dhangar,Stuart D. Greenhill,Gavin L. Woodhall,Paul Turko,Imre Vida,Craig C. Garner,Jonathan Wickel,Christian Geis,Yuko Fukata,Yuko Fukata,Masaki Fukata,Masaki Fukata,Harald Prüss,Harald Prüss,Harald Prüss +44 more
TL;DR: In this article, the authors demonstrate direct pathogenicity of autoantibodies on GABAA receptor (GABAAR) independent of Fc-mediated effector functions and provide an animal model for GABAAR encephalitis.
Journal ArticleDOI
A Sars-Cov-2 Neutralizing Antibody Protects from Lung Pathology in a Covid-19 Hamster Model
Jakob Kreye,S. Momsen Reincke,Hans-Christian Kornau,Elisa Sanchez-Sendin,Victor M. Corman,Hejun Liu,Meng Yuan,Nicholas C. Wu,Xueyong Zhu,Chang-Chun D Lee,Jakob Trimpert,Markus Hoeltje,Kristina Dietert,Laura Stoeffler,Niels von Wardenburg,Scott van Hoof,Marie A Homeyer,Julius Hoffmann,Azza Abdelgawad,Achim D. Gruber,Luca D. Bertzbach,Daria Vladimirova,Lucie Y Li,Paula Charlotte Barthel,Karl Skriner,Andreas C. Hocke,Stefan Hippenstiel,Martin Witzenrath,Norbert Suttorp,Florian Kurth,Christiana Franke,Matthias Endres,Dietmar Schmitz,Lara Maria Jeworowski,Anja Richter,Marie Luisa Schmidt,Tatjana Schwarz,Marcel A Mueller,Christian Drosten,Daniel Wendisch,Leif E. Sander,Nikolaus Osterrieder,Ian A. Wilson,Harald Pruess +43 more
TL;DR: Among 598 human monoclonal antibodies (mAbs) from ten SARS-CoV-2 patients, this article identified 40 strongly neutralizing mAbs, including CV07-209, which achieved IC 50 of 3.1 ng/ml.
Posted ContentDOI
Synapsin autoantibodies during pregnancy are associated with fetal abnormalities
I. Buenger,Jakob Kreye,Konstantin L. Makridis,Markus Hoeltje,H. Rasmussen-Foverskov,Scott van Hoof,Tino Ullrich,Elias D. Sedlin,D. D. Milovanović,Carolin Hoffmann,Franziska Paul,J. Meckies,Stefan Verlohren,Wolfgang Henrich,Rabija Chaoui,Angela M. Kaindl,H. Pruess +16 more
TL;DR: Seropositivity was strongly associated with abnormalities of fetal development including intrauterine growth retardation and indicates that these autoantibodies may be clinically useful developmental biomarkers and/or even directly participate in the disease process, thus being amenable to antibody-targeting interventional strategies in the future.