Sean Benler

TL;DR: The method used to produce a personalized bacteriophage-based therapeutic treatment for a 68-year-old diabetic patient with necrotizing pancreatitis complicated by an MDR A. baumannii infection suggests that the methods described here for the production of bacteriophile therapeutics could be applied to similar cases and that more concerted efforts to investigate the use of therapeutic bacteriaphages for MDR bacterial infections are warranted.

TL;DR: In this paper, a search of human gut metagenomes for circular contigs encoding phage hallmark genes resulted in the identification of 3738 apparently complete phage genomes that represent 451 putative genera.

TL;DR: Seeker is presented, a deep-learning tool for alignment-free identification of phage sequences that comprehensively validate Seeker's ability to identify previously unidentified phages, and employs this method to detect unknownphages, some of which are highly divergent from the known phage families.

TL;DR: The authors in this article analyzed 4907 Circular Metagenome Assembled Genomes (cMAGs) of putative viruses from human gut microbiomes and identified nearly 600 genomes of crAss-like phages that account for nearly 87% of the DNA reads mapped to these cMAGs.

TL;DR: It is shown that self and non-self recognition among some of the oldest extant holobionts involve bioactive lipids identical to those in highly derived taxa like humans, which further strengthens the hypothesis that major players of the immune response evolved during the pre-Cambrian.