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Sean Humphray
Researcher at Illumina
Publications - 86
Citations - 69908
Sean Humphray is an academic researcher from Illumina. The author has contributed to research in topics: Genome & Contig. The author has an hindex of 53, co-authored 86 publications receiving 60294 citations. Previous affiliations of Sean Humphray include Wellcome Trust Sanger Institute & Washington University in St. Louis.
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Journal ArticleDOI
Use of Genome Sequence Information for Meat Quality Trait QTL Mining for Causal Genes and Mutations on Pig Chromosome 17
TL;DR: High quality BAC sequences are obtained that cover a region on pig chromosome 17 where a number of meat quality QTL have been previously discovered and allowed identification of the chromosomal regions that likely contain the causative variants.
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Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags
Simon J. Hubbard,Darren Grafham,Kevin J. Beattie,Ian M. Overton,Stuart McLaren,Michael D. R. Croning,Paul E. Boardman,James K. Bonfield,Joan Burnside,Robert L. Davies,Elizabeth R. Farrell,Matthew D. Francis,Sam Griffiths-Jones,Sean Humphray,Christopher Hyland,Carol Scott,Haizhou Tang,Ruth Taylor,Cheryll Tickle,William Brown,Ewan Birney,Jane Rogers,Stuart A. Wilson +22 more
TL;DR: The data sets described here provide a transcriptome toolkit linked to physical clones for bioinformaticians and experimental biologists who wish to use chicken systems as a low-cost, accessible alternative to mammals for the analysis of vertebrate development, immunology, and cell biology.
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Evolutionary Breakpoints in the Gibbon Suggest Association between Cytosine Methylation and Karyotype Evolution
Lucia Carbone,R. Alan Harris,Gery M. Vessere,Alan R. Mootnick,Sean Humphray,Jane Rogers,Sung K. Kim,Jeffrey D. Wall,David D. Martin,Jerzy Jurka,Aleksandar Milosavljevic,Pieter J. de Jong +11 more
TL;DR: The association between undermethylation and chromosomal rearrangement in gibbons suggests a correlation between epigenetic state and structural genome variation in evolution.
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A Whole-Genome Mouse BAC Microarray With 1-Mb Resolution for Analysis of DNA Copy Number Changes by Array Comparative Genomic Hybridization
Yuen Jun Chung,J Jonkers,J Jonkers,Hannah Kitson,Heike Fiegler,Sean Humphray,Carol Scott,Sarah E. Hunt,Yuejin Yu,Ichiko Nishijima,Arno Velds,Henne Holstege,Nigel P. Carter,Allan Bradley +13 more
TL;DR: A mouse BAC microarray containing 2803 unique BAC clones from mouse genomic libraries at 1-Mb intervals is developed and reproducibly identified DNA copy number alterations in cell lines and primary tumors, such as single-copy deletions, regional amplifications, and aneuploidy.
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Convergent evolution in the genetic basis of Müllerian mimicry in heliconius butterflies.
Simon W. Baxter,Riccardo Papa,Nicola Chamberlain,Sean Humphray,Mathieu Joron,Clay Morrison,Richard H. ffrench-Constant,W. Owen McMillan,Chris D. Jiggins +8 more
TL;DR: Comparative genetic mapping shows red wing color loci are in homologous regions of the genome of H. erato and H. melpomene and implies they evolved independently using somewhat different developmental routes, but are nonetheless regulated by the same switch locus.