Sean P. Gunsten

TL;DR: The transient nature ofPrimary cilia, together with the temporal and spatial patterns of expression in the development and repair of airway epithelium, suggests a critical role of primary cilia in determining outcomes duringAirway epithelial cell differentiation.

TL;DR: It is indicated that autophagy is essential for airway mucus secretion in a type 2, IL13-dependent immune disease process and thereby provide a novel therapeutic strategy for attenuating airway obstruction in hypersecretory inflammatory diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis lung disease.

TL;DR: These findings demonstrate anti-inflammatory effects of azithromycin that are not related to anti-viral activity and support the rationale for future prospective randomized clinical trials that will evaluate the effects of macrolides on acute viral bronchiolitis and their long-term consequences.

TL;DR: The results show that minor particle modifications may significantly impact in vivo behavior within the complex environments of the lung, underscoring the need for animal modeling.

TL;DR: It is suggested that azithromycin may have beneficial effects in treating noninfectious airway inflammatory diseases, including asthma, after being demonstrated to attenuate the ovalbumin-dependent airway inflammation.