S
Sebastian Boland
Researcher at Harvard University
Publications - 21
Citations - 970
Sebastian Boland is an academic researcher from Harvard University. The author has contributed to research in topics: Lipid droplet & Unfolded protein response. The author has an hindex of 12, co-authored 19 publications receiving 589 citations. Previous affiliations of Sebastian Boland include Max Planck Society & Broad Institute.
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Journal ArticleDOI
Cardiac Magnetic Resonance Stress Perfusion Imaging for Evaluation of Patients With Chest Pain
Raymond Y. Kwong,Yin Ge,Kevin Steel,Scott Bingham,Shuaib M Abdullah,Kana Fujikura,Wei Wang,Ankur Pandya,Yi Yun Chen,J. Ronald Mikolich,Sebastian Boland,Andrew E. Arai,W. Patricia Bandettini,Sujata M Shanbhag,Amit R. Patel,Akhil Narang,Afshin Farzaneh-Far,Benjamin Romer,John F. Heitner,Jean Ho,Jaspal Singh,Chetan Shenoy,Andrew Hughes,Steve W. Leung,Meera Marji,Jorge A. Gonzalez,Sandeep Mehta,Dipan J. Shah,Dany Debs,Subha V. Raman,Avirup Guha,Victor A. Ferrari,Jeanette Schulz-Menger,Rory Hachamovitch,Matthias Stuber,Orlando P. Simonetti +35 more
TL;DR: In a multicenter U.S. cohort with stable chest pain syndromes, stress CMR performed at experienced centers offers effective cardiac prognostication.
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Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids
Manuele Piccolis,Laura M. Bond,Martin Kampmann,Pamela Pulimeno,Chandramohan Chitraju,Christina B. K. Jayson,Laura Pontano Vaites,Sebastian Boland,Zon Weng Lai,Katlyn R. Gabriel,Katlyn R. Gabriel,Shane D. Elliott,Shane D. Elliott,Joao A. Paulo,J. Wade Harper,Jonathan S. Weissman,Tobias C. Walther,Robert V. Farese,Robert V. Farese +18 more
TL;DR: Analysis of the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmitate revealed that changes in di-saturated glycerolipids, but not other lipid classes, are central to lipotoxicity in this model.
Journal ArticleDOI
Molecular Strategies of the Caenorhabditis elegans Dauer Larva to Survive Extreme Desiccation
Cihan Erkut,Andrej Vasilj,Sebastian Boland,Bianca Habermann,Andrej Shevchenko,Teymuras V. Kurzchalia +5 more
TL;DR: These data show that the desiccation response is activated by hygrosensation (sensing the desiccative environment) via head neurons, which leads to elimination of reactive oxygen species and xenobiotics, expression of heat shock and intrinsically disordered proteins, polyamine utilization, and induction of fatty acid desaturation pathway.
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Evolution of an endofungal Lifestyle: Deductions from the Burkholderia rhizoxinica Genome
Gerald Lackner,Nadine Moebius,Laila P. Partida-Martinez,Laila P. Partida-Martinez,Sebastian Boland,Christian Hertweck,Christian Hertweck +6 more
TL;DR: Modelling of evolution, metabolism and tools for host-symbiont interaction of the endofungal bacterium deduced from whole genome analyses suggests that B. rhizoxinica is in an early phase of adaptation to the intracellular lifestyle (genome in transition).
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APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
Grzegorz Sienski,Priyanka Narayan,Priyanka Narayan,Priyanka Narayan,Julia Maeve Bonner,Julia Maeve Bonner,Nora Kory,Sebastian Boland,Aleksandra Alicja Arczewska,William T. Ralvenius,Leyla Anne Akay,Elana Lockshin,Liang He,Blerta Milo,Agnese Graziosi,Valeriya Baru,Caroline A. Lewis,Manolis Kellis,David M. Sabatini,Li-Huei Tsai,Li-Huei Tsai,Susan Lindquist,Susan Lindquist +22 more
TL;DR: In this paper, the E4 allele of the apolipoprotein E gene (APOE) has been established as a genetic risk factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD).