S
Sebastián Dergan-Dylon
Researcher at Instituto de Biología y Medicina Experimental
Publications - 4
Citations - 710
Sebastián Dergan-Dylon is an academic researcher from Instituto de Biología y Medicina Experimental. The author has contributed to research in topics: Immune tolerance & Immune system. The author has an hindex of 4, co-authored 4 publications receiving 618 citations.
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Journal ArticleDOI
Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
Diego O. Croci,Juan P. Cerliani,Tomás Dalotto-Moreno,Santiago P. Méndez-Huergo,Ivan D. Mascanfroni,Sebastián Dergan-Dylon,Marta A. Toscano,Julio J. Caramelo,Juan J. Garcia-Vallejo,Jing Ouyang,Enrique A. Mesri,Melissa R. Junttila,Carlos Bais,Margaret A. Shipp,Mariana Salatino,Gabriel A. Rabinovich,Gabriel A. Rabinovich +16 more
TL;DR: A glycosylation-dependent pathway is identified that compensates for the absence of cognate ligand and preserves angiogenesis in response to VEGF blockade and may increase the efficacy of anti-VEGF treatment.
Journal ArticleDOI
Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease.
Tomás Dalotto-Moreno,Diego O. Croci,Juan P. Cerliani,Verónica C. Martinez-Allo,Sebastián Dergan-Dylon,Santiago P. Méndez-Huergo,Juan C. Stupirski,Daniel Mazal,Eduardo Osinaga,Marta A. Toscano,Victoria Sundblad,Gabriel A. Rabinovich,Mariana Salatino +12 more
TL;DR: The results offer a preclinical proof of concept that therapeutic targeting of Gal1 can overcome breast cancer-associated immunosuppression and can prevent metastatic disease.
Journal ArticleDOI
Nurse-like cells control the activity of chronic lymphocytic leukemia B cells via galectin-1
Diego O. Croci,Pablo Elías Morande,Sebastián Dergan-Dylon,Mercedes Borge,Marta A. Toscano,Juan C. Stupirski,Raimundo F. Bezares,Julio Cesar Sanchez Avalos,M Narbaitz,Romina Gamberale,Gabriel A. Rabinovich,Mirta Giordano +11 more
TL;DR: Nurse-like cells control the activity of chronic lymphocytic leukemia B cells via galectin-1 via Galectin1, and these cells act as “nurse- like cells” to reprogram B cells into T cells.
Journal ArticleDOI
Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications.
Ivan D. Mascanfroni,Juan P. Cerliani,Sebastián Dergan-Dylon,Diego O. Croci,Juan M. Ilarregui,Gabriel A. Rabinovich,Gabriel A. Rabinovich +6 more
TL;DR: In this paper, the role of protein-glycan interactions in dendritic cells' biology was investigated and the potential biomedical applications of these structurally-divergent but functionally-related lectins were discussed.