T
Tomás Dalotto-Moreno
Researcher at Instituto de Biología y Medicina Experimental
Publications - 17
Citations - 1038
Tomás Dalotto-Moreno is an academic researcher from Instituto de Biología y Medicina Experimental. The author has contributed to research in topics: Metastasis & Angiogenesis. The author has an hindex of 8, co-authored 16 publications receiving 765 citations. Previous affiliations of Tomás Dalotto-Moreno include National Scientific and Technical Research Council.
Papers
More filters
Journal ArticleDOI
Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
Diego O. Croci,Juan P. Cerliani,Tomás Dalotto-Moreno,Santiago P. Méndez-Huergo,Ivan D. Mascanfroni,Sebastián Dergan-Dylon,Marta A. Toscano,Julio J. Caramelo,Juan J. Garcia-Vallejo,Jing Ouyang,Enrique A. Mesri,Melissa R. Junttila,Carlos Bais,Margaret A. Shipp,Mariana Salatino,Gabriel A. Rabinovich,Gabriel A. Rabinovich +16 more
TL;DR: A glycosylation-dependent pathway is identified that compensates for the absence of cognate ligand and preserves angiogenesis in response to VEGF blockade and may increase the efficacy of anti-VEGF treatment.
Journal ArticleDOI
Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease.
Tomás Dalotto-Moreno,Diego O. Croci,Juan P. Cerliani,Verónica C. Martinez-Allo,Sebastián Dergan-Dylon,Santiago P. Méndez-Huergo,Juan C. Stupirski,Daniel Mazal,Eduardo Osinaga,Marta A. Toscano,Victoria Sundblad,Gabriel A. Rabinovich,Mariana Salatino +12 more
TL;DR: The results offer a preclinical proof of concept that therapeutic targeting of Gal1 can overcome breast cancer-associated immunosuppression and can prevent metastatic disease.
Journal ArticleDOI
Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk.
Carlos A. Orozco,Neus Martínez-Bosch,Pedro Enrique Guerrero,Judith Vinaixa,Tomás Dalotto-Moreno,Mar Iglesias,Mireia Moreno,Magdolna Djurec,Françoise Poirier,Hans-Joachim Gabius,Martin E. Fernandez-Zapico,Rosa F. Hwang,Carmen Guerra,Gabriel A. Rabinovich,Pilar Navarro +14 more
TL;DR: Gal1 hierarchically regulates different events implicated in PDA biology including tumor cell proliferation, invasion, angiogenesis, inflammation, and metastasis, highlighting the broad therapeutic potential of Gal1-specific inhibitors, either alone or in combination with other therapeutic modalities.
Journal ArticleDOI
Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression.
María Romina Girotti,Mariana Salatino,Tomás Dalotto-Moreno,Gabriel A. Rabinovich,Gabriel A. Rabinovich +4 more
TL;DR: The role of galectins in shaping cellular circuitries governing each hallmark of tumors is dissected, illustrating relevant examples and highlighting novel opportunities for treating human cancer.
Journal ArticleDOI
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid.
Guillermo L. Lehmann,Guillermo L. Lehmann,Christin Hanke-Gogokhia,Yang Hu,Rohan Bareja,Zelda Salfati,Michael Ginsberg,Daniel J. Nolan,Santiago P. Méndez-Huergo,Tomás Dalotto-Moreno,Alexandre Wojcinski,Francisca Ochoa,Shemin Zeng,Juan P. Cerliani,Lampros Panagis,Patrick J. Zager,Robert F. Mullins,Shuntaro Ogura,Gerard A. Lutty,Jakyung Bang,Jonathan H. Zippin,Carmelo Romano,Gabriel A. Rabinovich,Gabriel A. Rabinovich,Olivier Elemento,Alexandra L. Joyner,Shahin Rafii,Enrique Rodriguez-Boulan,Ignacio Benedicto,Ignacio Benedicto +29 more
TL;DR: The authors report the transcriptome of mouse retinal pigment epithelium/choroid tissue at single-cell resolution, which shows a subset of choroidal endothelial cells expresses Indian Hedgehog, which targets mesenchymal stem cell–like cells regulating mast cell survival and the inflammatory response after damage.