S
Sebastian Klein
Researcher at Biocrates Life Sciences AG
Publications - 2
Citations - 474
Sebastian Klein is an academic researcher from Biocrates Life Sciences AG. The author has contributed to research in topics: Bile acid & Deoxycholic acid. The author has an hindex of 2, co-authored 2 publications receiving 208 citations.
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Journal ArticleDOI
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.
Siamak Mahmoudiandehkordi,Matthias Arnold,Kwangsik Nho,Shahzad Ahmad,Wei Jia,Wei Jia,Guoxiang Xie,Gregory Louie,Alexandra Kueider-Paisley,M. Arthur Moseley,J. Will Thompson,Lisa St John Williams,Jessica D. Tenenbaum,Colette Blach,Rebecca Baillie,Xianlin Han,Sudeepa Bhattacharyya,Jon B. Toledo,Simon Schafferer,Sebastian Klein,Therese Koal,Shannon L. Risacher,Mitchel A. Kling,Alison A. Motsinger-Reif,Daniel M. Rotroff,John Jack,Thomas Hankemeier,David A. Bennett,Philip L. De Jager,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Cornelia M. van Duijn,Andrew J. Saykin,Gabi Kastenmüller,Rima Kaddurah-Daouk +36 more
TL;DR: This data indicates that BAs, products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria and seem dysregulated in Alzheimer's disease (AD).
Posted ContentDOI
Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease: An Emerging Role for Gut Microbiome
Siamak Mahmoudiandehkordi,Matthias Arnold,Kwangsik Nho,Shahzad Ahmad,Wei Jia,Guoxiang Xia,Gregory Louie,Alexandra Kueider-Paisley,M. Arthur Moseley,J. Will Thompson,Lisa St John Williams,Jessica D. Tenenbaum,Colette Blach,Rebecca Baillie,Xianlin Han,Sudeepa Bhattacharyya,Jon B. Toledo,Simon Schafferer,Sebastian Klein,Therese Koal,Shannon L. Risacher,Mitchel A. Kling,Alison A. Motsinger-Reif,Daniel M. Rotroff,John Jack,Thomas Hankemeier,David A. Bennett,Philip L. De Jager,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Cornelia M. van Duijn,Andrew J. Saykin,Gabi Kastenmüller,Rima Kaddurah-Daouk,Alzheimer's Disease Neuroimaging Initiative +36 more
TL;DR: An association between altered BA profile, genetic variants implicated in AD and cognitive changes in disease is reported using a large multicenter study and warrant further investigation of gut dysbiosis and possible role of gut liver brain axis in the pathogenesis of AD.