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Serge Picaud
Researcher at Vision Institute
Publications - 297
Citations - 10645
Serge Picaud is an academic researcher from Vision Institute. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 51, co-authored 269 publications receiving 8843 citations. Previous affiliations of Serge Picaud include University of Paris & Max Planck Society.
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Journal ArticleDOI
Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa
Volker Busskamp,Jens Duebel,D. Balya,Mathias Fradot,Mathias Fradot,Mathias Fradot,Tim J. Viney,Sandra Siegert,Anna C. Groner,Erik Cabuy,Valérie Forster,Valérie Forster,Valérie Forster,Mathias W. Seeliger,Martin Biel,Peter Humphries,Michel Paques,Saddek Mohand-Said,Didier Trono,Karl Deisseroth,José-Alain Sahel,Serge Picaud,Botond Roska +22 more
TL;DR: It is shown that expression of archaebacterial halorhodopsin in light-insensitive cones can substitute for the native phototransduction cascade and restore light sensitivity in mouse models of retinitis pigmentosa.
Journal ArticleDOI
Cellular retinol-binding protein I is essential for vitamin A homeostasis.
Norbert B. Ghyselinck,Claes Bavik,Vincent Sapin,Manuel Mark,Dominique Bonnier,Colette Hindelang,Andrée Dierich,Charlotte B. Nilsson,Helen Håkansson,Patrick Sauvant,Véronique Azaïs-Braesco,Maria Frasson,Serge Picaud,Pierre Chambon +13 more
TL;DR: CRBPI is indispensable for efficient RE synthesis and storage, and its absence results in a waste of ROL that is asymptomatic in vitA‐sufficient animals, but leads to a severe syndrome of vitA deficiency in animals fed a vitA-deficient diet.
Journal ArticleDOI
Light-emitting diodes (LED) for domestic lighting: any risks for the eye?
Francine Behar-Cohen,Francine Behar-Cohen,Christophe Martinsons,Françoise Viénot,Georges Zissis,A. Barlier-Salsi,J.P. Cesarini,Olivier Enouf,M. Garcia,Serge Picaud,Dina Attia +10 more
TL;DR: A comprehensive analysis of the potential risks of white LEDs is given, taking into account pre-clinical knowledge as well as epidemiologic studies and reports the French Agency's recommendations to avoid potential retinal hazards.
Journal ArticleDOI
Partial recovery of visual function in a blind patient after optogenetic therapy
José-Alain Sahel,Elise Boulanger-Scemama,Chloé Pagot,Angelo Arleo,Francesco Galluppi,Joseph N. Martel,Simona Degli Esposti,Alexandre Delaux,Jean-Baptiste de Saint Aubert,Caroline de Montleau,Emmanuel Gutman,Isabelle Audo,Jens Duebel,Serge Picaud,Deniz Dalkara,Laure Blouin,Magali Taiel,Botond Roska +17 more
TL;DR: This is the first reported case of partial functional recovery in a neurodegenerative disease after optogenetic therapy after intraocular injection of an adeno-associated viral vector encoding ChrimsonR with light stimulation via engineered goggles.
Journal ArticleDOI
Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
TL;DR: D-cis-diltiazem, a calcium-channel blocker that also acts at light-sensitive cGMP-gated channels, rescued photoreceptors and preserved visual function in the retinal degeneration mouse is reported.