S
Serge Romana
Researcher at Necker-Enfants Malades Hospital
Publications - 105
Citations - 10925
Serge Romana is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Chromosomal translocation & Fluorescence in situ hybridization. The author has an hindex of 34, co-authored 103 publications receiving 10290 citations. Previous affiliations of Serge Romana include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Salima Hacein-Bey-Abina,C von Kalle,C von Kalle,Manfred Schmidt,Matthew P. McCormack,NM Wulffraat,Philippe Leboulch,Annick Lim,Cameron S. Osborne,R. Pawliuk,Estelle Morillon,R. Sorensen,A. Forster,Peter Fraser,Jeffrey I. Cohen,G de Saint Basile,Ian E. Alexander,Uwe Wintergerst,Thierry Frebourg,Alain Aurias,Dominique Stoppa-Lyonnet,Serge Romana,I. Radford-Weiss,Fabian Gross,Françoise Valensi,Eric Delabesse,Elizabeth Macintyre,F. Sigaux,Jean Soulier,L. E. Leiva,Manuela Wissler,Claudia Prinz,Terence H. Rabbitts,F. Le Deist,Alain Fischer,Marina Cavazzana-Calvo +35 more
TL;DR: Retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.
Journal ArticleDOI
Mutation in TET2 in Myeloid Cancers
François Delhommeau,Sabrina Dupont,Véronique Della Valle,Chloé James,Séverine Trannoy,Aline Massé,Olivier Kosmider,Jean-Pierre Le Couedic,Fabienne Robert,Antonio José Alberdi,Yann Lécluse,Isabelle Plo,François Dreyfus,Christophe Marzac,Nicole Casadevall,Catherine Lacombe,Serge Romana,Philippe Dessen,Jean Soulier,Franck Viguié,Michaela Fontenay,William Vainchenker,Olivier Bernard +22 more
TL;DR: Somatic mutations in TET2 occur in about 15% of patients with various myeloid cancers and were present in hematopoietic stem cells and preceded the JAK2 V617F mutation in the five samples from patients with myeloproliferative disorders that were analyzed.
Journal ArticleDOI
Isolation by Size of Epithelial Tumor Cells : A New Method for the Immunomorphological and Molecular Characterization of Circulating Tumor Cells
Giovanna Vona,Abdelmajid Sabile,Malek Louha,Veronique Sitruk,Serge Romana,Karin Schütze,Frédérique Capron,Dominique Franco,Mario Pazzagli,Michel Vekemans,Bernard Lacour,Christian Bréchot,Patrizia Paterlini-Bréchot,Patrizia Paterlini-Bréchot +13 more
TL;DR: Evidence for the in vivo feasibility of ISET is provided in patients with hepatocellular carcinoma undergoing tumor resection and it is demonstrated that fluorescence in situ hybridization can be used to perform chromosomal analyses on tumor cells collected using ISET.
Journal ArticleDOI
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.
Serge Romana,M. Mauchauffe,M Le Coniat,I Chumakov,D Le Paslier,Roland Berger,Olivier Bernard +6 more
TL;DR: This translocation fused two genes, tel and AML1, that have previously been described in chromosomal translocations specific for myeloid malignancies, that belong to an increasing number of human genes that are involved in a variety of hematopoietic malignant disorders and can be rearranged with numerous partners.
Journal ArticleDOI
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia
Serge Romana,Hélène Poirel,M Leconiat,M. A. Flexor,M. Mauchauffe,Philippe Jonveaux,Elizabeth Macintyre,Roland Berger,Olivier Bernard +8 more
TL;DR: It is reported that fusion of TEL to AML1 is specifically observed in at least 16% of the childhood B-lineage acute lymphoblastic leukemia investigated, none of which had been previously identified as harboring t(12;21).