M
Matthew P. McCormack
Researcher at Monash University
Publications - 38
Citations - 5189
Matthew P. McCormack is an academic researcher from Monash University. The author has contributed to research in topics: Haematopoiesis & Leukemia. The author has an hindex of 21, co-authored 34 publications receiving 4898 citations. Previous affiliations of Matthew P. McCormack include University of Adelaide & Royal Melbourne Hospital.
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Journal ArticleDOI
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Salima Hacein-Bey-Abina,C von Kalle,C von Kalle,Manfred Schmidt,Matthew P. McCormack,NM Wulffraat,Philippe Leboulch,Annick Lim,Cameron S. Osborne,R. Pawliuk,Estelle Morillon,R. Sorensen,A. Forster,Peter Fraser,Jeffrey I. Cohen,G de Saint Basile,Ian E. Alexander,Uwe Wintergerst,Thierry Frebourg,Alain Aurias,Dominique Stoppa-Lyonnet,Serge Romana,I. Radford-Weiss,Fabian Gross,Françoise Valensi,Eric Delabesse,Elizabeth Macintyre,F. Sigaux,Jean Soulier,L. E. Leiva,Manuela Wissler,Claudia Prinz,Terence H. Rabbitts,F. Le Deist,Alain Fischer,Marina Cavazzana-Calvo +35 more
TL;DR: Retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.
Journal ArticleDOI
Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency
TL;DR: In two boys with X-linked severe combined immunodeficiency, a syndrome resembling T-cell leukemia developed in two of the boys, and the retrovirus integrated into the same genomic site, the locus of LMO2, which is involved in childhood lymphocytic leukemia.
Journal ArticleDOI
The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
Matthew P. McCormack,Matthew P. McCormack,Lauren F. Young,Sumitha Vasudevan,Carolyn A. de Graaf,Rosalind Codrington,Terence H. Rabbitts,Stephen M. Jane,Stephen M. Jane,David J. Curtis,David J. Curtis +10 more
TL;DR: Lmo2 promotes the self-renewal of preleukemic thymocytes, providing a mechanism by which committed T cells can then accumulate additional genetic mutations required for leukemic transformation.
Journal ArticleDOI
The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
TL;DR: It is concluded that there is no mandatory role for LMO2 in lymphoid development, implying that its specific role in T-cell tumorigenesis results from a reprogramming of gene expression after enforced expression inT-cell precursors.
Journal ArticleDOI
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.
Alan Forster,Richard Pannell,Lesley F Drynan,Matthew P. McCormack,Emma C Collins,Emma C Collins,Angelika Daser,Terence H. Rabbitts +7 more
TL;DR: It is demonstrated that developmentally regulated Cre-loxP-mediated interchromosomal recombination between the Mll gene, whose human counterpart is involved in a spectrum of leukemias, and the Enl gene creates reciprocal chromosomal translocations that cause myeloid tumors.