S
Shaji Chacko
Researcher at Baylor College of Medicine
Publications - 52
Citations - 1345
Shaji Chacko is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 17, co-authored 47 publications receiving 1028 citations. Previous affiliations of Shaji Chacko include United States Department of Agriculture.
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Journal ArticleDOI
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Annika S. Axelsson,Emily Tubbs,Brig Mecham,Shaji Chacko,Hannah Nenonen,Yunzhao Tang,Jed W. Fahey,Jonathan M. J. Derry,Claes B. Wollheim,Nils Wierup,Morey W. Haymond,Stephen H. Friend,Hindrik Mulder,Anders Rosengren,Anders Rosengren,Anders Rosengren +15 more
TL;DR: Sulforaphane was identified as a compound that may reverse the disease signature in the livers from diabetic animals and attenuated exaggerated glucose production and glucose intolerance by a magnitude similar to that of metformin.
Journal ArticleDOI
Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract.
Maaike A. Riedijk,Barbara J. Stoll,Shaji Chacko,Henk Schierbeek,Agneta L. Sunehag,Johannes B. van Goudoever,Douglas G. Burrin +6 more
TL;DR: It is shown here that 20% of the dietary methionine intake is metabolized by the GIT in piglets implanted with portal and arterial catheters and fed milk formula and is a significant site of net homocysteine production.
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Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs
TL;DR: It is concluded that SAA deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs.
Journal ArticleDOI
Gluconeogenesis during endurance exercise in cyclists habituated to a long-term low carbohydrate high-fat diet.
Christopher C. Webster,Timothy D. Noakes,Shaji Chacko,Jeroen Swart,Tertius Abraham Kohn,James Smith +5 more
TL;DR: In this article, the authors used stable isotope tracers to study glucose production kinetics during a 2-h ride in cyclists habituated to either a low carbohydrate high fat (LCHF) diet or a mixed macronutrient diet.
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New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs
Hester Vlaardingerbroek,Kenneth Ng,Barbara Stoll,Nancy M. Benight,Shaji Chacko,Leo A. J. Kluijtmans,Wim Kulik,E. James Squires,Oluyinka O. Olutoye,Deborah Schady,Milton L. Finegold,Johannes B. van Goudoever,Johannes B. van Goudoever,Johannes B. van Goudoever,Douglas G. Burrin +14 more
TL;DR: It is shown that TPN-fed pigs given soybean oil developed cholestasis and steatosis that was prevented with both OV and SL emulsions, and the differences in cholESTasis and liver injury among lipid emulsion groups in vivo were weakly correlated with plasma and hepatic phytosterol content.