J
Jonathan M. J. Derry
Researcher at Sage Bionetworks
Publications - 19
Citations - 3278
Jonathan M. J. Derry is an academic researcher from Sage Bionetworks. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 16, co-authored 19 publications receiving 2750 citations. Previous affiliations of Jonathan M. J. Derry include Merck & Co. & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Mapping the Genetic Architecture of Gene Expression in Human Liver
Eric E. Schadt,Cliona Molony,Eugene Chudin,Ke-Ke Hao,Xia Yang,Pek Yee Lum,Andrew Kasarskis,Bin Zhang,Susanna Wang,Christine Suver,Jun Zhu,Joshua Millstein,Solveig K. Sieberts,John Lamb,Debraj GuhaThakurta,Jonathan M. J. Derry,John D. Storey,Iliana Avila-Campillo,Mark J Kruger,Jason M. Johnson,Carol A. Rohl,Atila van Nas,Margarete Mehrabian,Thomas A. Drake,Aldons J. Lusis,Ryan Smith,F. Peter Guengerich,Stephen C. Strom,Erin G. Schuetz,Thomas H. Rushmore,Roger G. Ulrich +30 more
TL;DR: This genome-wide association study of gene expression resulted in the detection of more than 6,000 associations between SNP genotypes and liver gene expression traits, where many of the corresponding genes identified have already been implicated in a number of human diseases.
Journal ArticleDOI
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Menachem Fromer,Panos Roussos,Solveig K. Sieberts,Jessica S. Johnson,David H. Kavanagh,Thanneer M. Perumal,Douglas M. Ruderfer,Edwin C. Oh,Aaron Topol,Hardik Shah,Lambertus Klei,Robin Kramer,Dalila Pinto,Zeynep H. Gümüş,A. Ercument Cicek,Kristen K. Dang,Andrew W. Browne,Cong Lu,Lu Xie,Ben Readhead,Eli A. Stahl,Jianqiu Xiao,Mahsa Parvisi,Tymor Hamamsy,John F. Fullard,Ying-Chih Wang,Milind Mahajan,Jonathan M. J. Derry,Joel T. Dudley,Scott E. Hemby,Benjamin A. Logsdon,Konrad Talbot,Towfique Raj,Towfique Raj,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Jun Zhu,Bin Zhang,Patrick F. Sullivan,Patrick F. Sullivan,Andrew Chess,Shaun Purcell,Leslie A. Shinobu,Lara M. Mangravite,Hiroyoshi Toyoshiba,Raquel E. Gur,Chang-Gyu Hahn,David A. Lewis,Vahram Haroutunian,Mette A. Peters,Barbara K. Lipska,Joseph D. Buxbaum,Eric E. Schadt,Keisuke Hirai,Kathryn Roeder,Kristen J. Brennand,Nicholas Katsanis,Enrico Domenici,Bernie Devlin,Pamela Sklar +60 more
TL;DR: It is shown that schizophrenia is polygenic and the utility of this resource of gene expression and its genetic regulation for mechanistic interpretations of genetic liability for brain diseases is highlighted.
Journal ArticleDOI
Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
Ke Hao,Yohan Bossé,David C. Nickle,Peter D. Paré,Dirkje S. Postma,Michel Laviolette,Andrew J. Sandford,Tillie L. Hackett,Denise Daley,James C. Hogg,W. Mark Elliott,Christian Couture,Maxime Lamontagne,Corry-Anke Brandsma,Maarten van den Berge,Gerard H. Koppelman,Alise S. Reicin,Donald W. Nicholson,Vladislav A. Malkov,Jonathan M. J. Derry,Christine Suver,Jeffrey A. Tsou,Amit Kulkarni,Chunsheng Zhang,Rupert Vessey,Greg J. Opiteck,Sean P. Curtis,Wim Timens,Don D. Sin +28 more
TL;DR: The eQTLs and gene networks identified in this study are powerful tools for elucidating the causal mechanisms underlying pulmonary disease and providing much-needed support to pinpoint the causal genes and characterize the molecular function of gene variants associated with lung diseases.
Journal ArticleDOI
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Annika S. Axelsson,Emily Tubbs,Brig Mecham,Shaji Chacko,Hannah Nenonen,Yunzhao Tang,Jed W. Fahey,Jonathan M. J. Derry,Claes B. Wollheim,Nils Wierup,Morey W. Haymond,Stephen H. Friend,Hindrik Mulder,Anders Rosengren,Anders Rosengren,Anders Rosengren +15 more
TL;DR: Sulforaphane was identified as a compound that may reverse the disease signature in the livers from diabetic animals and attenuated exaggerated glucose production and glucose intolerance by a magnitude similar to that of metformin.
Posted ContentDOI
Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia
Menachem Fromer,Panos Roussos,Solveig K. Sieberts,Jessica S. Johnson,David H. Kavanagh,Thanneer M. Perumal,Douglas M. Ruderfer,Edwin C. Oh,Aaron Topol,Hardik Shah,Lambertus Klei,Robin Kramer,Dalila Pinto,Zeynep H. Gümüş,A. Ercument Cicek,Kristen K. Dang,Andrew W. Browne,Cong Lu,Li Xie,Ben Readhead,Eli A. Stahl,Mahsa Parvisi,Tymor Hamamsy,John F. Fullard,Ying-Chih Wang,Milind Mahajan,Jonathan M. J. Derry,Joel T. Dudley,Scott E. Hemby,Benjamin A. Logsdon,Konrad Talbot,Towfique Raj,David A. Bennett,Philip L. De Jager,Jun Zhu,Bin Zhang,Patrick F. Sullivan,Andrew Chess,Shaun Purcell,Leslie A. Shinobu,Lara M. Mangravite,Hiroyoshi Toyoshiba,Raquel E. Gur,Chang-Gyu Hahn,David A. Lewis,Vahram Haroutonian,Mette A. Peters,Barbara K. Lipska,Joseph D. Buxbaum,Eric E. Schadt,Keisuke Hirai,Kathryn Roeder,Kristen J. Brennand,Nicholas Katsanis,Enrico Domenici,Bernie Devlin,Pamela Sklar +56 more
TL;DR: Co-expression analyses identify a gene module that shows enrichment for genetic associations and is thus relevant for schizophrenia, paving the way for mechanistic interpretations of genetic liability for schizophrenia and other brain diseases.