S
Shao En Ong
Researcher at University of Washington
Publications - 95
Citations - 21414
Shao En Ong is an academic researcher from University of Washington. The author has contributed to research in topics: Proteomics & Kinase. The author has an hindex of 38, co-authored 81 publications receiving 20108 citations. Previous affiliations of Shao En Ong include University of Southern Denmark & University of Washington Medical Center.
Papers
More filters
Journal ArticleDOI
Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module.
Peter L. Hsu,Heng Li,Ho-Tak Lau,Calvin Jon Antolin Leonen,Abhinav Dhall,Shao En Ong,Champak Chatterjee,Ning Zheng,Ning Zheng +8 more
TL;DR: By spatially mapping the functional components of COMPASS, the results provide a structural framework for understanding the multifaceted functions and regulation of the H3K4 methyltransferase family.
Journal Article
CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma
Hui Liu,Shao En Ong,Kwabena Badu-Nkansah,Jeffrey W. Schindler,Forest M. White,Richard O. Hynes +5 more
Journal ArticleDOI
APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage
Lorenzo Lafranchi,Harmen R. de Boer,Elisabeth G.E. de Vries,Shao En Ong,Alessandro A. Sartori,Marcel A. T. M. van Vugt +5 more
TL;DR: It is shown that Cdh1 depletion causes increased levels of genomic instability and enhanced sensitivity to DNA‐damaging agents, and abrogating the CtIP–Cdh1 interaction results in delayed CtIP clearance from DNA damage foci, increased DNA‐end resection, and reduced homologous recombination efficiency.
Journal ArticleDOI
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing
Tao Zhang,Yen Ching Wu,Patrick C. Mullane,Yon Ju Ji,Hong-he Liu,Lu He,Amit Arora,Ho Yon Hwang,Amelia F. Alessi,Amirhossein Ghanbari Niaki,Goran Periz,Lin Guo,Hejia Wang,Elad Elkayam,Leemor Joshua-Tor,Sua Myong,John Kim,James Shorter,Shao En Ong,Anthony K.L. Leung,Jiou Wang +20 more
TL;DR: F fused in sarcoma (FUS), an RNA-binding protein linked to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), interacts with the core miRISC component AGO2 and is required for optimal microRNA-mediated gene silencing.
Journal ArticleDOI
Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis
Jarred W. Rensvold,Shao En Ong,Athavi Jeevananthan,Steven A. Carr,Vamsi K. Mootha,Vamsi K. Mootha,David J. Pagliarini +6 more
TL;DR: This work reveals that cellular iron is a key regulator of mitochondrial biogenesis, and provides quantitative data sets that can be leveraged to explore posttranscriptional and posttranslational processes that are essential for mitochondrial adaptation.